Beyond the transcriptome: completion of act one of the Immunological Genome Project.

Beyond the transcriptome: completion of act one of the Immunological Genome Project.
Curr Opin Immunol. 2013 Oct 26;
Authors: Kim CC, Lanier LL
Abstract
The Immunological Genome Consortium has generated a public resource (www.immgen.org) that provides a compendium of gene expression profiles of ∼270 leukocyte subsets in the mouse. This effort established carefully standardized operating procedures that resulted in a transcriptional dataset of unprecedented comprehensiveness and quality. The findings have been detailed recently in a series of publications providing molecular insights into the development, heterogeneity, and/or function of these cellular lineages and distinct subpopulations. Here, we review the key findings of these studies, highlighting what has been gained and how the knowledge can be used to accelerate progress toward a comprehensive understanding of the immune system.
PMID: 24168965 [PubMed - as supplied by publisher]

Source: Current Opinion in Immunology - October 26, 2013 Category: Allergy & Immunology Authors: Kim CC, Lanier LL Tags: Curr Opin Immunol Source Type: research