Differential frequency of CYP2R1 variants across populations reveals pathway selection for vitamin D homeostasis.

CONCLUSIONS: CYP2R1 polymorphisms have important effects on vitamin D homeostasis, and the geographic variability of CYP2R1 alleles represents an adaptation to differential exposures to UVB irradiation from sunlight.
PMID: 32115644 [PubMed - as supplied by publisher]

Source: The Journal of Clinical Endocrinology and Metabolism - March 1, 2020 Category: Endocrinology Authors: Casella A, Long C, Zhou J, Lai M, O'Lear L, Caplan I, Levine MA, Roizen JD Tags: J Clin Endocrinol Metab Source Type: research