Commentary: Remote Ischemic Preconditioning —Too Good to Be True?

In the late 1980s, in animal models of myocardial ischemia-reperfusion injury, short periods of temporary coronary occlusion led to decreased myocardial infarction size with subsequent coronary occlusion, a phenomenon termed ischemic preconditioning.1 Mitigation of ischemia-reperfusion injury was also noted when the infarcted area was in a different coronary distribution which had not been subjected to initial ischemia, an effect termed remote ischemic preconditioning (RIPC).2 Preconditioning was observed both when applied immediately prior to an ischemic insult (acute) or many hours before (delayed).

Source: Seminars in Thoracic and Cardiovascular Surgery - February 9, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Samuel Davila, Robert DB. Jaquiss Tags: CONGENITAL – Commentary Source Type: research