Review on Chemistry, Analysis, and pharmacology of teneligliptin: a novel DPP-4 inhibitor.

This article provides comprehensive and collective facts about teneligliptin. Teneligliptin is a dipeptide peptidase-4 (DPP-4) inhibitor belongs to the third generation, used in the management of type 2 diabetes. It inhibits human DPP-4 enzyme activity. This drug falls under class 3 as it interacts with the extensive sub-sites like S1, S2, and S2E. Teneligliptin and its metabolites mainly determined in human plasma matrix by hyphenated chromatographic methods. Theses developed methods could be foreseen for its clinical applications. Moreover, the stress degradation studies of teneligliptin under stress conditions along with identification of degraded product determined by liquid mass spectroscopy. These methods also used in routine quality control analysis of teneligliptin in pharmaceutical dosage forms. PMID: 32107992 [PubMed - as supplied by publisher]
Source: Mini Reviews in Medicinal Chemistry - Category: Chemistry Authors: Tags: Mini Rev Med Chem Source Type: research