MAPKAPK2 impairs replication of damaged DNA [Cell Biology]

DNA damage can obstruct replication forks, resulting in replicative stress. By siRNA screening, we identified kinases involved in the accumulation of phosphohistone 2AX (γH2AX) upon UV irradiation-induced replication stress. Surprisingly, the strongest reduction of phosphohistone 2AX followed knockdown of the MAP kinase-activated protein kinase 2 (MK2), a kinase currently implicated...

Source: Proceedings of the National Academy of Sciences - October 15, 2013 Category: Science Authors: Kopper, F., Bierwirth, C., Schon, M., Kunze, M., Elvers, I., Kranz, D., Saini, P., Menon, M. B., Walter, D., Sorensen, C. S., Gaestel, M., Helleday, T., Schon, M. P., Dobbelstein, M. Tags: Biological Sciences Source Type: research