Effects of Colesevelam on Bowel Symptoms, Biomarkers, and Colonic Mucosal Gene Expression in Patients with Bile Acid Diarrhea in a Randomized Trial

Approximately one-third of patients with IBS-diarrhea (IBS-D) have increased bile acid (BA) synthesis or excretion. An open-label study showed benefits of colesevelam on bowel functions, consistent with luminal BA sequestration by colesevelam. We compared the effects of colesevelam vs placebo on symptoms and gene expression patterns in the sigmoid colon mucosa in patients with BA diarrhea associated with IBS-D.

Source: Clinical Gastroenterology and Hepatology - February 19, 2020 Category: Gastroenterology Authors: Priya Vijayvargiya, Michael Camilleri, Paula Carlson, Asha Nair, Sara Linker Nord, Michael Ryks, Deborah Rhoten, Duane Burton, Irene Busciglio, Alan Lueke, W. Scott Harmsen, Leslie J. Donato Source Type: research