Macrophages produce collagen for myocardial scar formation

Nature Reviews Cardiology, Published online: 17 February 2020; doi:10.1038/s41569-020-0353-4Macrophages directly contribute collagen to scar formation as part of heart regeneration in zebrafish and heart repair in mice; this finding develops the current paradigm of collagen deposition for scar formation being generated exclusively via macrophage-mediated activation of cardiac fibroblasts to myofibroblasts.

Source: Nature Reviews Cardiology - February 16, 2020 Category: Cardiology Authors: Gregory B. Lim Source Type: research