Activation of autophagy inhibits NLRP3 inflammasome activation and attenuates myocardial ischemia ‐reperfusion injury in diabetic rats
ConclusionActivation of autophagy can suppress the NLRP3 inflammasome formation, which in turn attenuates myocardial ischemia reperfusion injury in diabetic rats.
CONCLUSION: Diabetes-specific screening instruments and/or specific screening questions should be used in outpatient routine care for young adults in a standardized manner, especially among young women, and the results should be discussed with the patients to initiate further treatment. PMID: 32252118 [PubMed - as supplied by publisher]
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Diabetic retinopathy (DR) is a common complication of diabetes and a leading cause of blindness among the working-age population. Diabetic patients often experience functional deficits in dark adaptation, contrast sensitivity and color perception before any microvascular pathologies on the fundus become detectable. Previously, we found that the regeneration of 11-cis-retinal and visual pigment is impaired in a type 1 diabetes animal model, which negatively affects the visual function at the early stage of DR.
This study investigated AF susceptibility and atrial electrophysiology in type 1 diabetic Akita mice using in vivo intracardiac electrophysiology, high-resolution optical mapping in atrial preparations, and patch clamping in isolated atrial myocytes. qPCR and...
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Conditions: Type 1 Diabetes; type1diabetes; Type 1 Diabetes Mellitus Interventions: Dietary Supplement: Lactobacillus plantarum; Other: Placebo Sponsor: Medical College of Wisconsin Not yet recruiting
(Joslin Diabetes Center) In people with type 1 diabetes without known cardiovascular disease, the presence of autoantibodies against heart muscle proteins was associated with cardiac magnetic resonance (CMR) imaging evidence of increased volume of the left ventricle (the heart's main pumping chamber), increased muscle mass, and reduced pumping function (ejection fraction), features that are associated with higher risk of failure in the general population
Many CpGs become hyper or hypo-methylated with age. Multiple methods have been developed by Horvath et al. to estimate DNA methylation (DNAm) age including Pan-tissue, Skin&Blood, PhenoAge, and GrimAge. Pan-...
The aim of the study was to establish whether suboptimal self-management explains the relationship between stressful life events and hemoglobin A1c (HbA1c) in adolescents with type 1 diabetes and whether these relationships differ across race/ethnicity.
To evaluate the changes in cardiovascular risk factors (CVRFs) and cardiovascular disease (CVD) in patients with type 1 diabetes (T1D) and end-stage renal disease (ESRD) who were candidates for kidney-pancreas transplantation (KPTx) from 1999 to 2017.