The immune microenvironment and neoantigen landscape of aggressive salivary gland carcinomas differ by subtype.

CONCLUSIONS: These findings provide new insights into the immune microenvironment and neoantigen landscape of SGCs, showing that mechanisms of immune escape appear to differ by histology. These data nominate potential immunologic vulnerabilities and may help guide the next steps of investigation in precision immunotherapy for these difficult-to-treat cancers. PMID: 32060100 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32060100?dopt=Abstract

Source: Clinical Cancer Research - February 13, 2020 Category: Cancer & Oncology Authors: Morris LG, Linxweiler M, Kuo F, Katabi N, Nadeem Z, Dalin MG, Makarov V, Chowell D, Dogan S, Ganly I, Hakimi AA, Wong RJ, Riaz N, Ho AL, Chan TA, Lee M Tags: Clin Cancer Res Source Type: research