Uptake of ¹⁸Ftetrafluoroborate in MCF-7 Breast Cancer Cells is Induced after Stimulation of the Sodium Iodide Symporter.

CONCLUSION: [18F]TFB was shown to be a promising hNIS-substrate in our model using the human MCF-7 breast cancer cell line mandating in vivo evaluations in xenografted studies and in patients. PMID: 32056515 [PubMed - in process]
Source: Current Cancer Drug Targets - Category: Cancer & Oncology Authors: Tags: Curr Cancer Drug Targets Source Type: research

Related Links:

Authors: Rinaldi I, Muthalib A, Astowo P, Irawan B, Susanto N, Magdalena L, Maha IHRT, Wicaksono S Abstract Global widespread of current coronavirus disease 2019 (COVID-19) pandemic has emerged huge predicament to healthcare systems globally. This disease caused by a new beta-type coronavirus, known as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), may lead to systemic multiorgan dysfunction syndrome and subsequently cause death due to abundant angiotensin converting enzyme 2 as its functional receptors throughout body. Oncology patients even have a worse prognosis with greater infection susceptibili...
Source: Acta medica Indonesiana - Category: Internal Medicine Tags: Acta Med Indones Source Type: research
By MICHEL ACCAD Last month marked the 400th anniversary of the birth of John Graunt, commonly regarded as the father of epidemiology.  His major published work, Natural and Political Observations Made upon the Bills of Mortality, called attention to the death statistics published weekly in London beginning in the late 16th century.  Graunt was skeptical of how causes of death were ascribed, especially in times of plagues.  Evidently, 400 years of scientific advances have done little to lessen his doubts!  A few days ago, Fox News reported that Colorado governor Jared Polis ...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: COVID-19 Medical Practice Physicians Diagnosis MICHEL ACCAD Source Type: blogs
Abstract BACKGROUND AND PURPOSE: To compare secondary malignancy risks of modern proton and photon therapy techniques for locally advanced breast cancer. METHODS AND MATERIALS: We utilized dosimetric data from 34 [10 photon-VMAT, 10 photon-3DCRT, 14 pencil beam scanning proton (PBS)] breast cancer patients who received comprehensive nodal irradiation. Employing a model based on organ equivalent dose to account for both inhomogeneous organ dose distributions and non-linear functional dose relationships, we estimated excess absolute risk, excess relative risk, and lifetime attributable risk (LAR) for secondary ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
1178Objectives: To evaluate the value of 18F-FES PET to differentiate between metastases originating from different tumor types. Content Overview: More and more patients acquire dual primary tumors, even multiple primary tumors, because of varied reasons, such as environmental modifications, genetic predisposition, therapy, increased surveillance, or prolonged survival. Identifying the origin of metastasis in patients with different primary tumors is a clinical dilemma. Although 18F-FDG PET / CT as whole-body scans might identify metastatic lesions, it lacks specificity and cannot distinguish the source of metastases in pa...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Oncology Poster Session (Educational Exhbits) Source Type: research
Conclusions: Limited [18F] NaF PET/CT (VMT) study acquisition is almost sufficient for diagnosis of most of neoplastic disease assessment providing less study time and lower CT-Scan absorbed dose. Reference: Ahuja, K., Sotoudeh, H., Galgano, S. J., Singh, R., Gupta, N., Gaddamanugu, S., &Choudhary, G. (2019). 18F-Sodium fluoride positron emission tomography: History, technical feasibility, mechanism of action, normal bio-distribution, and diagnostic performance in bone metastasis detection compared to other imaging modalities. Journal of Nuclear Medicine Technology, jnmt.119.234336.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Technologist Poster Session Source Type: research
1231Introduction: The sodium/iodide symporter (NIS) protein mediates transport of iodide into cells, and provides a key role in diagnosis and treatment of well-differentiated thyroid cancers. Surprisingly, breast cancer has recently been found to express hNIS in more than 75% of all sampled tumors 1. There is potential for NIS-mediated radiotracer imaging and radioiodide therapy in breast cancer, as it has been performed for decades in thyroid cancer under the same mechanisms. Some pretreatment agents such as retinoids alone or in combination with DEX have been used to enhance NIS expression and activity in breast cancer c...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Basic Oncology & amp; Translational (Poster Session) Source Type: research
RARITAN, NJ, May 13, 2020 – The Janssen Pharmaceutical Companies of Johnson &Johnson announced today results from the final analysis of the pivotal Phase 3 SPARTAN study demonstrating ERLEADA® (apalutamide) in combination with androgen deprivation therapy (ADT) significantly improved overall survival (OS), compared to ADT alone, in patients with non-metastatic castration-resistant prostate cancer (nmCRPC) who were at high risk of developing metastases.[i] Results will be presented at the American Society of Clinical Oncology (ASCO) Virtual Scientific Program (Abstract #5516) beginning May 29th. ERLEADA® i...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
Primary small cell carcinoma of the breast (SCCB) is a rare tumor subtype comprising
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
It’s in the early morning of April 15th, 2030 that when looking at your smart mirror, the latter beeps a warning notification: that new mole on your chin should be checked by your dermatologist. That was to be expected. After all your genetic test revealed that you possess a mutation in the CDKN2A gene. But you also get the recommendation to have your esophagus and stomach checked as your connected smart scale registered a noticeable drop in weight and this mutation also carries an increased risk of gastrointestinal (GI) tract cancer. With such increased awareness and early stage diagnosis methods, will the cance...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine Personalized Medicine cancer digital health cancer treatment digital technology oncology cancer research cancer care digital health technologies Source Type: blogs
Remember Monty Python’s brilliant Life of Brian movie scene where the Palestinian insurgent commando, planning the abduction of Pilate’s wife in return for all the horrors they had to endure from the Roman Empire, asks the rhetorical question: what have the Romans ever done for us? With the hype and overmarketing, not to speak about the fears around A.I, we asked the same question. What has A.I. in medicine ever done for us? Well, we found at least 45 things. I have 45 responses to the pressing question on everyone’s mind who is interested in healthcare but tired of the hype or the doomsday scenarios a...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Artificial Intelligence in Medicine Future of Medicine administration AI cancer diagnostics digital health digital health technology Healthcare Innovation medical medical imaging Radiology treatment Source Type: blogs
More News: Breast Cancer | Cancer | Cancer & Oncology | Nuclear Medicine | PET Scan | Sodium | Study | Thyroid | Thyroid Cancer