Endometrial expression of anti-müllerian hormone and its receptor type II in women with polycystic ovary syndrome

ConclusionsAlthough PCOS is associated with increased serum levels of AMH, protein expression of AMH and its receptor in the endometrium was not different to controls, and moreover not affected by lifestyle modification. Endometrial AMH-R immunostaining increased significantly during the menstrual cycle in both women with PCOS and controls. Our results imply that circulating AMH is not affecting expression of AMH and its receptor in the endometrium.The clinical trial registry numberID ISRCTN18400086.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research

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This study aimed to investigate the vitamin D status, and analyze the relationship between vitamin D deficiency and metabolic risk factors in PCOS women in Shaanxi China.Methods: A cross-sectional study included 169 women diagnosed with PCOS and 114 control women without PCOS. The serum 25(OH)D and metabolic markers were measured. Vitamin D deficiency was defined as serum 25(OH)D concentration less than 20 ng/mL. The primary outcome was the difference in vitamin D status between the PCOS and control groups, the secondary outcomes were correlations between serum 25(OH)D concentration and metabolic risk factors in women with...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Abstract Several studies have reported the association between polycystic ovary syndrome (PCOS) and low-grade chronic inflammation to be of uncertain cause: obesity, insulin resistance, or PCOS itself. The aim of the study was to investigate the WBC (white blood cell) count and CRP (C-reactive protein) concentration in women with PCOS and to determine the factors that affect their concentration. The study included 200 women aged 18-40 with PCOS and 105 healthy women as the control group, recruited in the Department of Gynaecological Endocrinology of Medical University in Warsaw from 2016 to 2018. Each patient unde...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
ConclusionOur simple evidence-based nomogram presents graphically risk factors and prognostic models for IVF/ICSI outcomes in patients with PCOS, which can offer useful guidance to clinicians and patients for individual adjuvant therapy.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
In conclusion, GJA1 may play a critical role in the development of oogenesis arrest in women with PCOS throughout the oogenesis processes, including oogenesis and oocyte maturation. PMID: 32190671 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Conclusions: Oral macronutrient challenges induced immediate class ‐specific postprandial changes in particle number and size of lipoproteins, with lipids inducing a more pro‐atherogenic lipoprotein profile compared with glucose and proteins, particularly in obese subjects and women with PCOS.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Research Article Source Type: research
Authors: Alissa EM, Algarni SA, Khaffji AJ, Al Mansouri NM Abstract Our aim was to investigate the relationship between plasma interleukin-6 (IL-6) levels with different measures of central obesity among Saudi women with and without polycystic ovarian syndrome (PCOS). One hundred and sixty-four Saudi females, between 22 and 38 years of age, with and without PCOS were enrolled in this case-control study. Physical examination and laboratory tests were completed for every subject. 2/3 of the study population were obese. Fasting serum insulin, plasma IL-6 levels and insulin resistance show significant increase amo...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
Source: Gynecological Endocrinology - Category: Endocrinology Authors: Source Type: research
Source: Gynecological Endocrinology - Category: Endocrinology Authors: Source Type: research
Abstract OBJECTIVES: To explore if and how the microbiota changed in PCOS women against healthy women. METHODS: Eight obese PCOS (PO group), ten non-obese PCOS (PN group) and nine healthy normal-weight women (control) (C group) were enrolled. Insulin (INS), testosterone (T), follicle-stimulating hormone (FSH), luteinizing hormone (LH), estrogen (E2) and dehydroepiandrosterone (DHEA) were detected with radioimmunoassay. Anti mullerian hormone (AMH), fasting glucose and hemoglobin A1c (HbA1c) were determined by chemiluminescence immunoassay, glucose oxidase method and HPLC, respectively. Gut microbiota composit...
Source: Canadian Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Can J Physiol Pharmacol Source Type: research
CONCLUSION: In PCOS, increases in NFκB activation and circulating CRP and decreases in IκBα protein following saturated fat ingestion are independent of obesity. Circulating MNC and excess adipose tissue are separate and distinct contributors to inflammation in this disorder. PMID: 32140727 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
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