Angiomatous hyperplasia in the heart of a young rat.

Angiomatous hyperplasia in the heart of a young rat. J Toxicol Pathol. 2020 Jan;33(1):29-32 Authors: Piccicuto V, Dincer Z, Walker S, Gray C Abstract This case report describes angiomatous hyperplasia in the heart which is an unusual location in a young male Sprague-Dawley rat in a short-term toxicity study. Histologically, the lesion was characterized by blood-filled vascular channels of variable diameter lined by a thin wall and surrounded by a thin fibrous stroma and minimal lympho-plasmacytic and neutrophilic infiltrate in the apex of the heart. Immunohistopathology using CD31 confirmed the blood vessel origin, and using Ki67 confirmed low cell-proliferative activity in the vascular endothelial cells. To the authors' knowledge, this is the first report of spontaneous angiomatous hyperplasia in the heart of a young rat. PMID: 32051663 [PubMed]
Source: Journal of Toxicologic Pathology - Category: Toxicology Tags: J Toxicol Pathol Source Type: research