Studies pertaining to the monitoring of volatile halogenated anaesthetics in breath by proton transfer reaction mass spectrometry

Post-operative isoflurane has been observed to be present in the end-tidal breath of patients who
have undergone major surgery, for several weeks after the surgical procedures. A major new
non-controlled, non-randomized, and open-label approved study will recruit patients undergoing
various surgeries under different inhalation anaesthetics, with two key objectives, namely (1) to
record the washout characteristics following surgery, and (2) to investigate the influence of a
patient ’s health and the duration and type of surgery on elimination. In preparation for this breath
study using proton transfer reaction time-of-flight mass spectrometry (PTR-TOF-MS), it is important
to identify first the analytical product ions that need to be monitored and under what operating
conditions. In this first paper of this new research programme, we present extensive PTR-TOF-MS
studies of three major anaesthetics used worldwide, desflurane (CF 3 CHFOCHF 2 ), sevoflurane ((CF
...

Source: Journal of Breath Research - February 13, 2020 Category: Respiratory Medicine Authors: Michaela Mal ásková, David Olivenza-León, Prema D Chellayah, Judith Martini, Wolfgang Lederer, Veronika Ruzsanyi, Karl Unterkofler, Paweł Mochalski, Tilmann D Märk, Peter Watts and Chris A Mayhew Source Type: research