Apolipoprotein A-I concentrations and risk of coronary artery disease: A Mendelian randomization study

Apolipoprotein A-I (apoA-I) infusions represent a potential novel therapeutic approach for the prevention of coronary artery disease (CAD). Although circulating apoA-I concentrations inversely associate with risk of CAD, the evidence base of this representing a causal relationship is lacking. The aim was to assess the causal role of apoA-I using human genetics.

Source: Atherosclerosis - February 12, 2020 Category: Cardiology Authors: Minna K. Karjalainen, Michael V. Holmes, Qin Wang, Olga Anufrieva, Mika K ähönen, Terho Lehtimäki, Aki S. Havulinna, Kati Kristiansson, Veikko Salomaa, Markus Perola, Jorma S. Viikari, Olli T. Raitakari, Marjo-Riitta Järvelin, Mika Ala-Korpela, Johann Source Type: research