GSE126956 A maternally inherited polymorphism in mitochondrial genome alters immune cell metabolism and protects mice from skin inflammation

Contributors : Hauke Busch ; Saleh Ibrahim ; Misa Hirose ; Paul SchilfSeries Type : Expression profiling by arrayOrganism : Mus musculusSeveral mitochondrial genetic variants have been associated with different chronic inflammatory diseases. However, experimental proof for the pathogenic relevance of these associations is still missing. We have reported that polymorphisms in the mitochondrial gene MT-ATP8, which encodes a subunit of the mitochondrial ATP synthase, are associated with the autoimmune skin disease bullous pemphigoid. Using a mouse model for this disease, we show here that a SNP in mt-Atp8 determine the severity of autoantibody-induced skin inflammation by modulating T effector cell function and shifting the levels of short chain fatty acids. With respect to the latter, increased levels of propionate are associated with milder disease, and systemic administration of propionate ameliorates disease. By employing the Aldara ™-induced psoriasiform dermatitis model, we further demonstrate that the immunomodulatory effects of mt-Atp8 variants are also relevant for autoinflammation. Collectively, our results highlight discrete mitochondrial genetic variants as significant general modulators of skin inflammation and possi bly of other organs.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research

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Authors: Esch T, Stefano GB, Ptacek R, Kream RM Abstract Over the past two decades, a major goal of our research group has been elucidation of the functional roles of several key regulatory molecules in proinflammatory preconditioning involved in the pathophysiology of seemingly diverse human disease states. By necessity, operational definitions of proinflammation must be intrinsically fluid based on recent advances in our understanding of complex regulation of innate and adaptive immune processes. Similar to systemic acute stress, a physiological proinflammatory state appears to be a key autoregulatory mechanism f...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
A group of moderately ill people were given hydroxychloroquine, which appeared to ease their symptoms quickly, but more research is needed.
Source: NYT - Category: American Health Authors: Tags: Coronavirus (2019-nCoV) Hydroxychloroquine (Drug) Drugs (Pharmaceuticals) Quarantines Shortages Autoimmune Diseases Pneumonia Immune System Malaria Schaffner, William your-feed-healthcare Source Type: news
CONCLUSION: Our results indicated that MSC-secretome had DPP-IV/CD26 and APN/CD13 activity. The DPP-IV/CD26 activity was decreased following stimulation of MSCs by toll-like receptor 4 agonist. Further studies are needed to reveal the possible contribution of DPP-IV/CD26 and APN/CD13 in the anti-inflammatory functions of MSC-CM. PMID: 32224540 [PubMed - in process]
Source: Iranian Journal of Immunology - Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research
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Source: Current Opinion in Nephrology and Hypertension - Category: Urology & Nephrology Tags: RENAL IMMUNOLOGY AND PATHOLOGY: Edited by Agnes B. Fogo Source Type: research
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Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
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Source: Current Opinion in Clinical Nutrition and Metabolic Care - Category: Nutrition Tags: PAEDIATRICS: Edited by Berthold Koletzko and Raanan Shamir Source Type: research
A local biotech is rethinking how to treat autoimmune diseases. It's raised $80 million to do it.
Source: Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Contributors : Xuehua Piao ; Ryosuke Miura ; Ryodai Shindo ; Hiroyasu NakanoSeries Type : Expression profiling by arrayOrganism : Mus musculusCellular FLICE-inhibitory protein (cFLIP) prevents the development of dermatitis by blocking TNF α-dependent apoptosis of keratinocytes. However, it is unclear whether TNFα-independent signal might also contribute to the development of dermatitis in epidermis-specific Cflar-deficient (Cflar) mice. Here we show that Cflar;Tnfrsf1a-/- mice were born at the expected Mende lian ratio, but developed severe dermatitis and succumbed soon after birth. Whil...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
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Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (1155) Source Type: research
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