5 Challenges in the Treatment & Diagnosis of Lupus

A recent study published in Lupus Science &Medicine lays out five of the top barriers impeding progress in lupus diagnosis and treatment.1 The Addressing Lupus Pillars for Health Advancement project (ALPHA), led by the Lupus Foundation of America (LFA), researchers at the Tufts School of Medicine Center for the Study of Drug Development (Tufts... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Research Reviews SLE (Lupus) Access to care adherence Biomarkers clinical trials heterogeneity Socioeconomic Impact Source Type: research

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US president called Modi and threatened ‘retaliation’ if country kept full export banCoronavirus – latest updatesSee all our coronavirus coverageIndia has approved some exports ofhydroxychloroquine, an anti-malaria drug being touted as a possible coronavirus treatment, after apparent pressure from Donald Trump, who has been urging Americans to take it.The tablets are used to prevent and treat malaria, lupus and rheumatoid arthritis but over the past week the US president has been aggressively promoting the drug as a treatment for coronavirus, despite there being no conclusive medical evidence to prove its...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: India South and Central Asia World news US news Malaria Coronavirus outbreak Infectious diseases Medical research Science Source Type: news
Health officials have sent hydroxychloroquine, typically used to treat malaria and lupus, to 56 hospitals across New York to treat patients suffering serious complications from the virus.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Conclusion: We identified virome signatures associated with SLE, which might help develop tools to identify SLE patients or predict the disease stage.
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Condition:   Systemic Lupus Erythematosus Intervention:   Behavioral: TEACH Sponsors:   Michigan State University;   Arthritis Foundation;   The Hospital for Sick Children;   Montefiore Medical Center Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Contributors : Parisa Amini ; Sina Nassiri ; Julia Ettlin ; Alexandra Malbon ; Enni MarkkanenSeries Type : Expression profiling by high throughput sequencingOrganism : Canis lupus familiarisCancer-associated stroma (CAS) and matched normal stroma (NS) samples from 13 cases of canine mammary adenoma
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Canis lupus familiaris Source Type: research
Increased leucine-rich α2-glycoprotein-1 (LRG1) has been observed in various inflammatory and autoimmune diseases. We aimed to explore the expression and role of LRG1 in lupus nephritis (LN).
Source: BMC Nephrology - Category: Urology & Nephrology Authors: Tags: Research article Source Type: research
Xenon, an inert anesthetic gas, is increasingly recognized to possess desirable properties including cytoprotective and anti-inflammatory effects. Here we evaluated the effects of xenon on the progression of lupus nephritis (LN) in a mouse model. A two hour exposure of either 70% xenon or 70% nitrogen balanced with oxygen was administered daily for five weeks to female NZB/W F1 mice that had been induced to develop accelerated and severe LN. Xenon treatment improved kidney function and renal histology, and decreased the renal expression of neutrophil chemoattractants, thereby attenuating glomerular neutrophil infiltration.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: basic research Source Type: research
In this study, we systematically evaluated the changes in B cell activation induced by the Xbp1 splicing inhibitor STF083010 in a pristane-induced lupus mouse model. The lupus mouse model was successfully established, as indicated by the presence of LN with markedly increased urine protein levels, renal deposition of Ig and mesangial cell proliferation. In lupus mice, B cell hyperactivity was confirmed by increased CD40 and B cell activating factor (BAFF) levels. B cell activation and plasma cell overproduction were determined by increases in CD40+ and CD138+ cells in the spleens of lupus mice by flow cytometry and further...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research
We present the case of PCNSL which developed in a patient with the active phase of neuropsychiatric SLE (NPSLE). Furthermore, we reviewed published English articles to confirm the chara cteristics of PCNSL related to SLE. To our knowledge, this is the first report of PCNSL occurring in NPSLE. Histology demonstrated B-cell lymphoma with a positive Epstein–Barr virus-encoded RNA. This patient recovered following surgical resection of the lymphoma, whole brain radiation therapy, int ravenous infusion of rituximab (RTX), and administration of belimumab after RTX. Given the series of reviews, our report suggests that the ...
Source: Rheumatology International - Category: Rheumatology Source Type: research
Authors: Zhang S, Deng Y, Huang X, Li N, Fan H, Xiang B, Wu Y, Cheng X, Chen X Abstract OBJECTIVES: We sought to analyse the expression characteristics of cytochrome C oxidase subunit I in mitochondrial of MRL/lpr lupus mice. METHODS: The whole blood of MRL/lpr lupus mice was detected for whole mitochondrial genome sequencing performed by Illumina HiSeq PE150 instrument, compared with house mouse (NC_005089.1) and screened for the maximum difference gene, MT-CO1. Quantitative real-time polymerase chain reaction (qRT-PCR) and western blot were used to detect the mRNA and protein expression of MT-CO1 in lupus mic...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
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