Photopolymerized Starch Nanoparticle (SNP) Network Hydrogels

Publication date: Available online 12 February 2020Source: Carbohydrate PolymersAuthor(s): Michael J. Majcher, Carter L. McInnis, Sebastian Himbert, Richard J. Alsop, Dennis Kinio, Markus Bleuel, Maikel C. Rheinstädter, Niels M.B. Smeets, Todd HoareAbstractStarch is an attractive biomaterial given its low cost and high protein repellency, but its use in forming functional hydrogels is limited by its high viscosity and crystallinity. Herein, we demonstrate the use of fully amorphous starch nanoparticles (SNPs) as functional hydrogel building blocks that overcome these challenges. Methacrylation of SNPs enables hydrogel formation via photopolymerization, with the low viscosity of SNPs enabling facile preparation of pre-gel suspensions of up to 35 wt% SNPs relative to <10 wt% with linear starch. Small angle neutron scattering indicates a significantly different microstructure in SNP-based hydrogels compared to linear starch-based hydrogels due to the balance between inter- and intra-particle crosslinks, consistent with SNPs forming denser and stiffer hydrogels. Functionalized SNPs are highly cytocompatible at degree of substitution values <0.25 and, once gelled, can effectively repel cell adhesion. The physicochemical versatility and biological functionality of SNP-based hydrogels offer potential in various applications.
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research