A water-stable Zn(II)-based metal-organic framework for selective detection of Fe3+ ion and treatment effect on children asthma by reducing apoptosis of eosinophil

Publication date: Available online 13 February 2020Source: Inorganica Chimica ActaAuthor(s): Wenjie Wang, Ang Ge, Hongfeng Zhu, Peili YangAbstractThe selective detection of metal ion is of high importance to the environmental protection and the safety of human health. In this paper, a novel fluorescent metal-organic framework containing Zn(II) ions as the metal nodes based {Zn3(OH)} clusters as the secondary building unit (SBU) and a rigid hexacarboxylic acid linker of 5,5′,5''-(methylsilanetriyl)triisophthalic acid (H6L) has been triumphantly prepared under the solvothermal conditions, and its chemical formula is established to be {[Zn3HL(μ3-OH)(H2O)2]∙3(H2O)∙DMA}n (1, DMA = N,N-dimethylacetamide). Due to its considerable water stability, the high sensitivity and selectivity of complex 1 as the fluorescent sensor for the detection of the Fe3+ ion in aqueous solution were studied. Furthermore, the treatment function of complex against the children asthma was evaluated and the related mechanism was explored. Firstly, the reverse transcription-polymerase chain reaction (RT-PCR) was carried out in order to determine the bcl-2 gene relative expression level, and the cell apoptosis level was determined with cell apoptosis detection kit. Finally, for the in vivo detection, the children asthma model was constructed and the release of the MBP and EDN from eosinophils was detected by the enzyme linked immunosorbent assay (ELISA).Graphical abstract
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research