Differential cystine and dibasic amino acid handling after loss-of-function of the amino acid transporter b0,+AT (Slc7a9) in mice.

In conclusion, loss of Slc7a9 function decreases the glomerular filtration rate and increases the excretion of several amino acids to a lesser extent than expected with no clear regulation at the mRNA and protein level of alternative transporters and no increased renal epithelial uptake. These observations indicate that transporters located in distal segments of the kidney and/or metabolic pathways may partially compensate Slc7a9 loss of function.
PMID: 24107421 [PubMed - as supplied by publisher]

Source: Am J Physiol Renal P... - October 9, 2013 Category: Urology & Nephrology Authors: Di Giacopo A, Rubio-Aliaga I, Cantone A, Artunc F, Rexhepaj R, Frey-Wagner I, Font-Llitjós M, Gehring N, Stange G, Jaenecke I, Mohebbi N, Closs EI, Palacín M, Nunes V, Daniel H, Lang F, Capasso G, Wagner CA Tags: Am J Physiol Renal Physiol Source Type: research