Development of a reliable and selective voltammetric method for determination of designer drug 1-(3-chlorophenyl)piperazine (mCPP) using boron-doped diamond electrode and exploiting surfactant-mediated measurements

Publication date: Available online 5 February 2020Source: Sensors and Actuators B: ChemicalAuthor(s): Luana Rianne Rocha, Jhessica de Cássica Mendonça, Tainara Boareto Capelari, Roberta Antigo Medeiros, César Ricardo Teixeira TarleyAbstract1-(3-chlorophenyl) piperazine (mCPP) is a drug abuse and its considered as one of the most well-known piperazine derivatives, exhibiting ecstasy-like stimulants and hallucinogenic effects, thereby its determination in drugs seized is of paramount importance. Electroanalysis offers a good alternative for in situ testing on seized samples, but the development of new electroanalytical methods for piperazine derivatives is still incipient. In this work, an electroanalytical method for mCPP detection and quantification using a catodically pre-treated boron-doped diamond electrode (CPT-BDDE) has been reported for the first time. Cyclic voltammograms obtained for mCPP in 0.5 mol L-1 H2SO4 evidenced an electrochemical irreversible behavior with an anodic peak at 1.1 V. Under the optimum condition using differential pulse voltammetry, 0.5 mol L-1 Britton-Robinson buffer and pH 10, the proposed method provided an analytical curve linear over a mCPP concentration range of 3.5 to 400.0 µmol L-1, with a limit of detection of 1.1 μmol L-1. Adulterants commonly found in seized drugs, including lidocaine (LID), acetominophen (PAR), acetylsalicylic acid (AAS), caffeine (CAF), benzocaine (BEN), procaine (PRO), phenacetine (PHE), cocaine (C...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research