Clinical evaluation of an in-house panfungal real-time PCR assay for the detection of fungal pathogens

ConclusionIn combination with routine methods, our panfungal PCR assay is a valuable diagnostic tool. Patients at risk for invasive fungal infections might profit from the reduced time to pathogen identification.
Source: Infection - Category: Infectious Diseases Source Type: research

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Publication date: 15 August 2020Source: Food Chemistry, Volume 321Author(s): Ye Sun, Renfu Lu, Leiqing Pan, Xiaochan Wang, Kang Tu
Source: Food Chemistry - Category: Food Science Source Type: research
Authors: Papachristou SG, Iosifidis E, Sipsas NV, Gamaletsou MN, Walsh TJ, Roilides E Abstract Introduction: Osteoarticular fungal infections (OAFIs) complicate the clinical course of high-risk patients, including immunosuppressed individuals. Their management, however, despite being intricate, is governed by evidence arising from sub-optimal quality research, such as case series. Guidelines are scarce and when present result in recommendations based on low quality evidence. Furthermore, the differences between the management of immunocompromised and immunocompetent patients are not distinct. This is a narrative re...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
We describe the case of a 37  years old female carrier of X-linked CGD, who presented with clinical features and serology consistent with a definite diagnosis of Systemic Lupus Erythematosus (SLE), with rare immune mediated neurological manifestations including secondary Central Nervous System (CNS) vasculitis and Longitudina lly Extensive Transverse Myelitis (LETM), responsive to immunomodulation.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Tags: Short Communication Source Type: research
Publication date: Available online 27 March 2020Source: Journal of Microbiology, Immunology and InfectionAuthor(s): He Wang, Yao Wang, Qi-Wen Yang, Yu-Xing Ni, Li-Kai Lin, Yan-Ping Luo, Zi-Yong Sun, Min Li, Wen-Juan Wu, Qiang-Qiang Zhang, Dan-Hong Su, Hua Yu, Mei Kang, He-Ping Xu, Wei Liu, Qing Yang, Cui Jian, Li-Na Guo, Wen-Hang Yang, Meng Xiao
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
AbstractPurpose of ReviewSkin infections caused by yeasts are becoming more frequent, mainly the ones associated withCandida albicans. However, the non-albicansCandida species are emerging with new species that have lower susceptibility and greater resistance to antifungal agents. Therefore, the objective of this review is to learn about the newCandida emerging species that are causing skin infections, their diagnosis, and treatment.Recent FindingsNew emerging species that cause skin disease have been found such asC. duobushaemulonii,C. africana, andC. auris, the latter being a health problem due to its difficult identific...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
AbstractPurpose of ReviewThis review summarizes current treatment options for echinocandin-resistantCandida spp. (ERC) and azole-resistantAspergillus fumigatus (ARAF), emphasizing recent in vitro/in vivo data, clinical reports, and consensus statements.Recent FindingsAdvances in ERC and ARAF treatment are limited to specific antifungal combinations and dose optimization but remain reliant on amphotericin products. Although novel antifungals may provide breakthroughs in the treatment of resistant fungi, these agents are not yet available. Early identification and appropriate treatment remain a paramount, albeit elusive, tas...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
Authors: Đorđević Betetto L, Žgavec B, Bergant Suhodolčan A Abstract Tinea incognita is an atypical presentation of fungal infection of the skin, the clinical presentation of which has been modified by misuse of topical corticosteroids or calcineurin inhibitors. Such dermatophyte infections often have an atypical clinical presentation and are difficult to diagnose, but with the rise of immunosuppressive drugs and self-prescribed topical therapies, they are becoming increasingly prevalent. Here we report the case of a 68-year-old male patient with a history of psoriasis, presenting with erythematous scaly lesio...
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - Category: Dermatology Tags: Acta Dermatovenerol Alp Pannonica Adriat Source Type: research
Trichosporon asahii is a rare opportunistic fungal pathogen that causes fatal systemic infection in immunocompromised patients. Neutropenia developing due to malignancies is an important risk factor for fungal infection. Invasive infections due to T. asahii can be divided into disseminated and localized forms. The disseminated form is more common and usually occurs in neutropenic patients. The patient typically has an acute febrile illness that progresses rapidly to multiorgan failure. Here, we are presenting a case of fungal sepsis by invasive T. asahii in a 1-year-old child with Wilms Tumor. To the best of our knowledge,...
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research
This article explores new perspectives on the mechanisms of antifungal acridine-peptide conjugates and acridine-based hybrid molecules to effectively combat fungal infections.
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
Human histoplasmosis is a fungal infection caused by the inhalation of microconidia of the thermally dimorphic fungi Histoplasma capsulatum. Autochthonous cases of histoplasmosis have been diagnosed in almost every country, but it is considered an endemic infection in specific areas of the world. Many of them are popular travel destinations or the source of migratory movements. Thus, the vast majority of the registered cases in non-endemic countries are imported. They correspond to people having been exposed to the fungus in endemic locations as immigrants, expatriates, transient workers or tourists, with reported cases al...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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