Allosteric activation of MALT1 by its ubiquitin-binding Ig3 domain [Immunology and Inflammation]

The catalytic activity of the protease MALT1 is required for adaptive immune responses and regulatory T (Treg)-cell development, while dysregulated MALT1 activity can lead to lymphoma. MALT1 activation requires its monoubiquitination on lysine 644 (K644) within the Ig3 domain, localized adjacent to the protease domain. The molecular requirements for MALT1...

Source: Proceedings of the National Academy of Sciences - February 10, 2020 Category: Science Authors: Rebekka Schairer, Gareth Hall, Ming Zhang, Richard Cowan, Roberta Baravalle, Frederick W. Muskett, Peter J. Coombs, Chido Mpamhanga, Lisa R. Hale, Barbara Saxty, Justyna Iwaszkiewicz, Chantal Decaillet, Mai Perroud, Mark D. Carr, Margot Thome Tags: Biological Sciences Source Type: research