Axenfeld-Rieger Anomaly and Neuropsychiatric Problems —More than Meets the Eye
Conclusion We report on the co-occurrence of ocular anterior segment dysgenesis (Axenfeld-Rieger anomaly) and neuropsychiatric symptoms as clinical signs of genetically determined cerebral small vessel disease in two patients. In both patients, the cerebral lesions involved the frontotemporal regions, brain regions that control social behavior as well as executive and cognitive function, highlighting the fact that neuropsychiatric symptoms may be early clinical presentations of cerebral small vessel disease. We further provide a review of monogenic causes of pediatric cerebral small vessel disease, emphasizing the links to childhood-onset neuropsychiatric disease. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Neuropediatrics - Category: Neurology Authors: Saffari, Afshin Ziegler, Andreas Merkenschlager, Andreas Kr üger, Stefan K ölker, Stefan Hoffmann, Georg Friedrich Syrbe, Steffen Tags: Original Article Source Type: research