Information Integration and Mesoscopic Cortical Connectivity during Propofol Anesthesia

Conclusions The genuine permutation cross mutual information reflected propofol-induced coupling changes measured at a cortical scale. Loss of consciousness was associated with a redistribution of the pattern of information integration; losing efficient global information transmission capacity but increasing local functional segregation in the cortical network.Editor ’s PerspectiveWhat We Already Know about This TopicCoupling of neuronal oscillations between brain regions is correlated with higher level brain activityPermutation cross mutual information can be used to evaluate information integration in the electroencephalogram during anesthesia.What This Article Tells Us That Is NewUsing electrocorticography in subjects anesthetized with propofol, the genuine permutation cross mutual information demonstrated that, with loss of consciousness, there was a loss of efficient global information transmission and increased local functional segregation in the cortical network

Source: Anesthesiology - February 12, 2020 Category: Anesthesiology Source Type: research