Cerebrospinal fluid biomarkers implicated in the pathogenesis of anti-neutrophil cytoplasmic antibody-related hypertrophic pachymeningitis

ConclusionThe levels of BAFF, APRIL, and TGF- β1 may serve as useful CSF biomarkers for assessing the disease activity of immune-mediated HP. Moreover, BAFF and APRIL in the CSF may be implicated in the pathogenesis of ANCA-HP via promoting autoreactive B cells, while detecting MPO- or PR3-ANCA in the CSF may be found in some patients with ANC A-HP.Key Points•CSF BAFF, APRIL, and TGF- β1 levels increase significantly in immune-mediated HP.•CSF BAFF and APRIL levels are significantly correlated with IgG index in ANCA-HP.•Detection of MPO- or PR3-ANCA in the CSF is found in some patients with ANCA-HP.•BAFF, APRIL, and ANCA in the CSF may be implicated in the pathogenesis of ANCA-HP.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research