Histologic Comparison of the Dura Mater among Species.

Histologic Comparison of the Dura Mater among Species. Comp Med. 2020 Feb 03;: Authors: Kinaci A, Bergmann W, Bleys RL, van der Zwan A, van Doormaal TP Abstract The biocompatibility, biodegradation, feasibility, and efficacy of medical devices like dural sealants and substitutes are often evaluated in various animal models. However, none of these studies explain the rationale for choosing a particular species, and a systematic interspecies comparison of the dura is not available. We hypothesized that histologic characteristics of the dura would differ among species. We systematically investigated basic characteristics of the dura, including thickness, composition, and fibroblast orientation of the dura mater, in 34 samples representing 10 animal species and compared these features with human dura by using hematoxylin and eosin staining and light microscopy. Dura showed many similarities between species in terms of composition. In all species, dura consisted of at least one fibrovascular layer, which containedcollagen, fibroblasts, and blood vessels, and a dural border cell layer beneath the fibrovascular layer. Differences betweenspecies included the number of fibrovascular layers, fibroblast orientation, and dural thickness. Human dura was the thickest(564 μm) followed by equine (313 μm), bovine (311 μm), and porcine (304 μm) dura. Given the results of this study and factors such as gross anatomy, feasibility, housing, and ethic...
Source: Comparative Medicine - Category: Zoology Authors: Tags: Comp Med Source Type: research