Gynaecological Cancer Diagnostics: 99mTc-Cisplatin Complex as a Future Approach for Early, Prompt and Efficient Diagnosis of Gynaecological Cancer.

CONCLUSION: This article summarizes the significance of radioscintigraphy such as single-photon emission computed tomography (SPECT) and PET for identification of GCCa in the experimental humans and animals. PMID: 32008509 [PubMed - in process]
Source: Current Medical Imaging Reviews - Category: Radiology Tags: Curr Med Imaging Rev Source Type: research

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Cancers, Vol. 12, Pages 1868: Development of Antibody Immuno-PET/SPECT Radiopharmaceuticals for Imaging of Oncological Disorders—An Update Cancers doi: 10.3390/cancers12071868 Authors: Jonatan Dewulf Karuna Adhikari Christel Vangestel Tim Van Den Wyngaert Filipe Elvas Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are molecular imaging strategies that typically use radioactively labeled ligands to selectively visualize molecular targets. The nanomolar sensitivity of PET and SPECT combined with the high specificity and affinity of monoclonal antibodies have sh...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
In this study, scintigraphy and single-photon emission computed tomography/computed tomography images after radioactive iodine treatment revealed a physiological uptake of radioactive iodine due to lacrimal secretion around an artificial eyeball; such findings have not been reported previously.
Source: Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
Conclusion: The high accumulation of activity in the tumor and fast clearance from background organs was a common favorable characteristic of PSMA radioligands modified with ibuprofen as albumin-binding entity. 177Lu-Ibu-DAB-PSMA emerged as the most promising candidate; hence, more detailed preclinical investigations with this radioligand are warranted in view of a clinical translation.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Conclusion: This work demonstrates a means for efficient dose estimation in 177Lu-PSMA-617 therapy. By providing methods to simplify and potentially automate radiation dosimetry, we hope to accelerate the understanding of radiobiology and development of dose–response models in this unique therapeutic context.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Clinical Source Type: research
An artificial intelligence (AI) neural network used with lung CT scans can...Read more on AuntMinnie.comRelated Reading: Diagnostic brain imaging overused for lung cancer Mobile CT improves access to lung cancer screening AI predicts lung cancer survival from CT scan data SABR plus surgery is effective for treating lung cancer New SPECT tracer targets NSCLC receptor
Source: Headlines - Category: Radiology Source Type: news
In this study, a PNA sequence that undergoes complementary binding to miR-155 was labeled with 99mTc to evaluate whether the tracer could visualize the expression of miR-155 in breast cancer. Both antisense PNA (anti-PNA, fully complementary bound to human mature miR-155, referred to as "anti-PNA-155") and mismatched PNA (referred to as "mis-PNA") single strands containing 23-mer were synthesized. The relative expression of miR-155 in MCF-7 cells and tumors was higher than that in MDA-MB-231 cells and tumors. Single-photon emission computed tomography (SPECT) scan showed that radioactivity mainly accumu...
Source: Molecular Imaging - Category: Radiology Tags: Mol Imaging Source Type: research
AbstractMetabolic bone volume (MBV), standardized uptake value (SUV), and total bone uptake (TBU) are new imaging biomarkers for quantitative bone single-photon emission computed tomography/computed tomography. The purpose of this study was to validate the quantitative accuracy and utility of MBV, SUVmean, and TBU for the assessment of bone metastases in prostate cancer. We used a bone-specific phantom with four hot spheres (φ = 13, 17, 22, 28 mm) filled with different Tc-99 m activities to simulate uptake ratios of 3 and 7, corresponding to normal and metastatic values. We calculated the error ...
Source: Radiological Physics and Technology - Category: Physics Source Type: research
The past two decades have brought impressive advancements in immune modulation, particularly with the advent of both cancer immunotherapy and biologic therapeutics for inflammatory conditions. However, the dynamic nature of the immune response often complicates the assessment of therapeutic outcomes. Innovative imaging technologies are designed to bridge this gap and allow non-invasive visualization of immune cell presence and/or function in real time. A variety of anatomical and molecular imaging modalities have been applied for this purpose, with each option providing specific advantages and drawbacks. Anatomical methods...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusions: All compound were successfully prepared. All final products exhibited high stability in human serum and saline, as well as selective uptake in cardiomyocyte cells in vitro. 18F-HX01 and 18F-HX06 display high and persistent cardiac uptake over 2 h with high myocardium-to-lung and myocardium-to-liver ratio in healthy mice in PET imaging, which were also observed in biodistribution studies. Advancement of these radiotracers for MPI imaging is currently underway.Fig 1. Synthesis route for the reference standards, precursors and radio-labeled products.Fig 2. Static PET imaging of 18F-HX01 in rat (30 mins post injec...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Cardiovascular Basic Science (Poster Session) Source Type: research
Conclusions: This pilot study indicated that the uptake of HER2 antagonist 99mTc-HPArk2 correlate with HER2 expression in breast cancer. 99mTc-HPArk2 SPECT/CT can provide specific, non-invasive evaluation of HER2 expression in breast cancer.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Breast Cancer I Source Type: research
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