Reducing a model of sugar metabolism in peach to catch different patterns among genotypes.

Reducing a model of sugar metabolism in peach to catch different patterns among genotypes. Math Biosci. 2020 Jan 31;:108321 Authors: Kanso H, Quilot-Turion B, Memah MM, Bernard O, Gouzé JL, Baldazzi V Abstract Several studies have been conducted to understand the dynamic of primary metabolisms in fruit by translating them into mathematics models. An ODE kinetic model of sugar metabolism has been developed by Desnoues et al. [1] to simulate the accumulation of different sugars during peach fruit development. Two major drawbacks of this model are (a) the number of parameters to calibrate and (b) its integration time that can be long due to non-linearity and time-dependent input functions. Together, these issues hamper the use of the model for a large panel of genotypes, for which few data are available. In this paper, we present a model reduction scheme that explicitly addresses the specificity of genetic studies in that: i) it yields a reduced model that is adapted to the whole expected genetic diversity ii) it maintains network structure and variable identity, in order to facilitate biological interpretation. The proposed approach is based on the combination and the systematic evaluation of different reduction methods. Thus, we combined multivariate sensitivity analysis, structural simplification and timescale-based approaches to simplify the number and the structure of ordinary differential equations of the model. The original and...
Source: Mathematical Biosciences - Category: Statistics Authors: Tags: Math Biosci Source Type: research