Glutamate and Dysconnection in the Salience Network: Neurochemical, Effective-connectivity, and Computational Evidence in Schizophrenia

Functional dysconnection in schizophrenia is underwritten by a pathophysiology of the glutamate neurotransmission that affects the excitation-inhibition balance in key nodes of the salience network. Physiologically, this is manifest as aberrant effective connectivity in intrinsic connections involving inhibitory interneurons. In computational terms, this produces a pathology of evidence accumulation and ensuing inference in the brain. Finally, the pathophysiology and aberrant inference would partially account for the psychopathology of schizophrenia as measured in terms of symptoms and signs.

Source: Biological Psychiatry - February 4, 2020 Category: Psychiatry Authors: Roberto Limongi, Peter Jeon, Michael Mackinley, Tushar Das, Kara Dempster, Jean Th éberge, Robert Bartha, Dickson Wong, Lena Palaniyappan Tags: Archival Report Source Type: research