Impact of internal target volume definition for pencil beam scanned proton treatment planning in the presence of respiratory motion variability for lung cancer: A proof of concept.

CONCLUSION: Irregular respiration significantly affects CTV coverage when ITVs are only defined by single 4DCTs. A probabilistic ITV50 provides an adequate compromise between target coverage and lung dose for most motion and patient scenarios investigated.
PMID: 32007759 [PubMed - as supplied by publisher]

Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 29, 2020 Category: Radiology Authors: Krieger M, Giger A, Salomir R, Bieri O, Celicanin Z, Cattin PC, Lomax AJ, Weber DC, Zhang Y Tags: Radiother Oncol Source Type: research