Dihydro-β-agarofuran-type sesquiterpenes from the roots of Tripterygium wilfordii and their cytotoxic activity

Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Yi-Yu Jiang, Ban-Ban Li, Na Li, Xiao Meng, Xin Lin, Dong Wang, Da-Xi Xiong, Ya-Nan Sun, Li Chen, Long CuiAbstractTwenty-one β-dihydroagarofuran-type sesquiterpenes compounds were isolated from the dry roots of Tripterygium wilfordii, including eight new β-dihydroagarofuran-type sesquiterpenes nature products (2, 6, 8-13) and thirteen known compounds, the structure of these compounds were elucidated by extensive NMR spectroscopic and mass spectrometric analysis. Among all isolated compound 10 exhibited cytotoxicity toward five carcinoma cells, including A549, HOS, MCF-7, MDA-MB-231 and MCF7/TAMR cells, with half-maximal inhibition of cell proliferation values ranging from 13.77 to 25.19 μM.Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research