Increased number of intratumoral IL-17+ cells, a harbinger of the adverse prognosis of triple-negative breast cancer

ConclusionThe study indicates that IL-17 is overexpressed in intratumoral stromal cells of TNBC-NST. The overexpression of IL-17 might engage in active tumor microangiogenesis through its signal transduction pathways resulting in increased tumor secretion of VEGFA, and then promote tumor progression. IL-17 might serve as a potential new target for individualized therapy to TNBC-NST patients by development of specific antibodies. Additional study is deemed to further explore the role of IL-17+ stromal cells in breast cancer.

http://link.springer.com/10.1007/s10549-020-05540-6

Source: Breast Cancer Research and Treatment - January 28, 2020 Category: Cancer & Oncology Source Type: research