A Monte Carlo model for organ dose reconstruction of patients in pencil beam scanning (PBS) proton therapy for epidemiologic studies of late effects
Significant efforts such as the Pediatric Proton/Photon Consortium Registry (PPCR) involving
multiple proton therapy centers have been made to conduct collaborative studies evaluating outcomes
following proton therapy. As a groundwork dosimetry effort for the late effect investigation, we
developed a Monte Carlo (MC) model of proton pencil beam scanning (PBS) to estimate organ/tissue
doses of pediatric patients at the Maryland Proton Treatment Center (MPTC), one of the proton
centers involved in the PPCR. The MC beam modeling was performed using the TOPAS (TOol for PArticle
Simulation) MC code and commissioned to match measurement data within 1% for range, and 0.3 mm for
spot sizes. The established MC model was then tested by calculating organ/tissue doses for sample
intracranial and craniospinal irradiations on whole-body pediatric computational human phantoms. The
simulated dose distributions were compared with the treatment planning system dose distributions,
showing the 3 mm...
Source: Journal of Radiological Protection - Category: Physics Authors: Yeon Soo Yeom, Gleb Kuzmin, Keith Griffin, Matthew Mille, Jerimy Polf, Ulrich Langner, Jae Won Jung, Choonik Lee, Dillon Ellis, Jungwook Shin and Choonsik Lee Source Type: research