Validation of the Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-55 and QOLCE-16) for use by parents of young adults with childhood-onset epilepsy

The objective of the study was to validate the parent-proxy reported Quality of Life in Childhood Epilepsy Questionnaire (QOLCE) in a sample of young adults with a history of childhood-onset epilepsy, allowing for the utilization of a consistent informant (the parent) across the youths' stages of development. The 55-item (QOLCE-55) and 16-item versions (QOLCE-16) were evaluated.MethodsData came from 134 young adults (aged 18.0 to 28.5 years) with childhood-onset epilepsy, recruited through community and tertiary care centers across Canada. Confirmatory factor analysis (CFA) was used to assess the higher-order factor structure of the QOLCE. Cronbach's alpha was used to evaluate internal consistency. Convergent validity was assessed by intraclass correlation coefficients (ICC) with the youth self-reported Quality of Life in Epilepsy Questionnaire (QOLIE-31-P).ResultsThe higher-order factor structure of the QOLCE-55 and QOLCE-16 demonstrated adequate fit: QOLCE-55 comparative fit index (CFI) = 0.968, Tucker–Lewis index (TLI) = 0.966; and root mean square of approximation (RMSEA) = 0.061; QOLCE-16 CFI = 0.966, TFI = 0.959, RMSEA = 0.141. Higher-order factor loadings were strong, ranging from 0.71 to 0.90. Internal consistency was excellent for the total score (αQOLCE-55 = 0.97; αQOLCE-16 = 0.93) and good-excellent for each subscale (α > 78). Convergent validity was moderate to good for the total score (ICC > ...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research

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Publication date: Available online 25 February 2020Source: NeuropsychologiaAuthor(s): Shawniqua Williams Roberson, Preya Shah, Vitória Piai, Heather Gatens, Abba M. Krieger, Timothy H. Lucas, Brian Litt
Source: Neuropsychologia - Category: Neurology Source Type: research
Publication date: April 2020Source: Epilepsy &Behavior, Volume 105Author(s): Mariana de Souza Aranha Garcia-Gomes, Dennis Albert Zanatto, Orfa Yineth Galvis-Alonso, Jorge Mejia, Ana Tada Fonseca Brasil Antiorio, Pedro Kenzo Yamamoto, Márcia Carolina Millán Olivato, Thaísa Meira Sandini, Jorge Camilo Flório, Ivo Lebrun, Silvia Maria Gomes Massironi, Sandra Regina Alexandre-Ribeiro, Maria Martha Bernardi, Susan Ienne, Tiago Antonio de Souza, Maria Lúcia Zaidan Dagli, Claudia Madalena Cabrera Mori
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Authors: Si Y, Xiao X, Xia C, Guo J, Hao Q, Mo Q, Niu Y, Sun H Abstract OBJECTIVE: To assess whether a practical intervention based upon a smartphone application (app) would improve self-management and seizure control in adults with epilepsy. DESIGN, SETTING: Randomised, controlled trial in western China, December 2017 to August 2018. PARTICIPANTS: 380 eligible people with epilepsy were recruited; 327 completed the 6-month follow-up (176 in the app group, 151 in the control group). MAIN OUTCOME MEASURES: Self-management of epilepsy (measured with the validated Chinese Epilepsy Self-Management Scale, C-E...
Source: Medical Journal of Australia - Category: General Medicine Tags: Med J Aust Source Type: research
An epileptic man's death "may have been prevented" by better follow-up care, an inquest hears.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
Condition:   Epilepsy Intervention:   Device: Sensor Dot Sponsors:   Universitaire Ziekenhuizen Leuven;   Freiburg University;   King's College London;   Oxford University Hospital;   University of Coimbra;   Karolinska Institutet;   RWTH Aachen University;   UCB Pharma;   Byteflies;   Helpilepsy Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Conditions:   Healthy Participants;   Epilepsy Interventions:   Drug: Padsevonil type 1 Tablet 200 mg;   Drug: Padsevonil type 2 Tablet;   Drug: Padsevonil type 3 Tablet;   Drug: Padsevonil type 4 Tablet;   Drug: Padsevonil type 5 Tablet Sponsor:   UCB Biopharma SRL Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Condition:   Epilepsy, Tonic-Clonic Intervention:   Other: Accelerometer Live-Streaming Tool Sponsor:   LivaNova Not yet recruiting
Source: - Category: Research Source Type: clinical trials
What’s worth some 1,204.8 billion USD? Well, it’s the worldwide pharmaceutical market, of course! With such a capital at stake and with the pace of technological disruption, the pharma industry is quick to adapt to the changing times. In fact, leading drug companies are re-investing as much as 20.8% of drug sales into new drug development.  We’ve analyzed the trends shaping the future of pharma before, but how can we expect to see the landscape evolve in this new decade? With leaps in A.I., patient empowerment and 3D printed drugs, here are the 5 aspects that will be the focus of pharmaceutical co...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Pharma digital health future of medicine pharmaceutics digital health companies Source Type: blogs
We report the use of acute deep brain stimulation (DBS) to evoke behavioral and emotional effects by applying electrical stimulation (ES) at various voltage strengths to the basolateral and central subnuclei of the amygdala in addition to the head of hippocampus (HC) for two subjects with medically refractory post-traumatic stress disorder (PTSD). Our results suggest that the amygdala could be a node in a neural network responsible for the generation of complex vivid mental imagery and integrated sensory experiences similar to John Hughlings Jackson’s “dreamy state” and “double consciousness,”...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
ConclusionsThe majority of these patients were managed without clinically significant perioperative complications. As previously reported, bradycardia, hypotension, and hypothermia were the most common adverse events. Routine avoidance of propofol in patients with Batten disease does not appear warranted.
Source: Journal of Anesthesia - Category: Anesthesiology Source Type: research
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