Synthesis of Carbon-dots@SiO2@TiO2 Nanoplatform for Photothermal Imaging Induced Multimodal Synergistic Antitumor

Publication date: Available online 25 January 2020Source: Journal of Advanced ResearchAuthor(s): Bing Wei, Fei Dong, Wei Yang, Chunhua Luo, Qiujing Dong, Zuoqin Zhou, Zheng Yang, Liangquan ShengAbstractFor facilitating theranostic nanoplatform with multimodal therapeutic ability, we develop the core-shell structured CDs@SiO2@TiO2 nanoplatforms (CST NPs). The designed CST NPs possess excellent photothermal effect and fluorescence resonance energy transfer (FRET) induced photodynamic property, which could achieve synergistic photothermal and photodynamic therapy. Meanwhile, the photothermal ability of CST NPs acts as a key role in the application of real-time photothermal imaging, benefitting for the diagnosis of tumor accurately. Moreover, the obtained CST NPs also exhibit outstanding sonodynamic effect with huge potential for sonodynamic therapy. Under the 650 nm laser irradiation, the synthesized CST NPs not only inhibit the growth of cancer cells in vitro, but also display precise photothermal imaging and photo-induced ablation to tumor in vivo. As a result, the prepared CST NPs may potentially serve as multifunctional nanoplatform for theranostic antitumor and pave the avenue for clinic cancer therapy.Graphical abstractA nanoplatform could perform excellent photothermal therapy and fluorescence resonance energy transfer induced photodynamic therapy for real-time photothermal imaging guided synergistic phototherapy of cancer.
Source: Journal of Advanced Research - Category: Research Source Type: research