Osteogenesis imperfecta in a male Holstein calf associated with a possible oligogenic origin.

Conclusion: The analysis of the OI case revealed a possible oligogenic origin of the disease attributable to additive effects of three candidate genes, i.e. ABCA13, QRFPR, and IFTIM5.Clinical relevance: Most OI cases in humans and domestic animals reported so far are caused by distinct dominant or recessive monogenic mutations, therefore a potential oligogenic additive genetic effect is a novel finding. Furthermore, the case presented here demonstrates that cross-species genetic analyses might not always be straightforward. PMID: 31980012 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31980012?dopt=Abstract

Source: Veterinary Quarterly - January 26, 2020 Category: Veterinary Research Tags: Vet Q Source Type: research