Allergo-oncology: what allergologists and oncologists can learn from each other : Regulatory T cells in allergy and cancer.
CONCLUSION: Regulatory T cells play an important role in the pathogenesis of cancer and allergies, and thus represent a therapeutic target. PMID: 31970443 [PubMed - as supplied by publisher]
C-type lectin receptors (CLRs) are important in several immune regulatory processes. These receptors recognize glycans expressed by host cells or by pathogens. Whereas pathogens are recognized through their glycans, which leads to protective immunity, aberrant cellular glycans are now increasingly recognized as disease-driving factors in cancer, auto-immunity, and allergy. The vast variety of glycan structures translates into a wide spectrum of effects on the immune system ranging from immune suppression to hyper-inflammatory responses. CLRs have distinct expression patterns on antigen presenting cells (APCs) controlling t...
ConclusionOur study does not support a causal effect of allergic disease on the risk of breast or prostate cancer. Future studies may be conducted to focus on understanding the causal role of allergic disease in cancer prognosis or drug responses (e.g., immunotherapy).
Roche's immunotherapy Tecentriq failed a late-stage clinical trial in a form of urothelial cancer, the Swiss drugmaker said on Friday.Reuters Health Information
B cells and tertiary lymphoid structures (TLS) play key roles in promoting cancer immunotherapy responses, according to results from three studies published in Nature.Reuters Health Information
Publication date: March 2020Source: Biomedicine &Pharmacotherapy, Volume 123Author(s): Abdolreza Esmaeilzadeh, Safa Tahmasebi, Seyyed Shamsadin AthariAbstractDespite the current advancements, cancer treatment approaches have limitations restricting their cure rate. Immunotherapy techniques are among novel and promising cancer therapeutic approaches. Therapeutic antibodies and adoptive cell therapy (ACT) are the main branches of immunotherapy. T lymphocytes and genetically engineered cells are among important cells which can be used in ACT. This review has focused on recent advances in engineered cell-based immunotherap...
British drugmaker AstraZeneca Plc said on Friday its immunotherapy cancer treatment Imfinzi (durvalumab) has been granted a speedy review by the U.S. medicines watchdog for the treatment of a particularly aggressive type of lung cancer.Reuters Health Information
Swiss drugmaker Roche on Friday said its immunotherapy Tecentriq combined with its Avastin medicine helped people with the most common form of liver cancer to live longer than with an older drug from Germany's Bayer.Reuters Health Information
For patients without a healthy immune system, immunotherapy could supercharge symptoms, but a new study is shedding light on how to go about treating cancer in patients with autoimmune diseases.Medscape Medical News
Immunotherapy appears to be safe and effective for treating non-small-cell lung cancer (NSCLC) in older people, researchers from Italy report.Reuters Health Information
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