Toll-like receptor 3 increases antigen-presenting cell responses to a pro-apoptotic stimulus, yet does not contribute to systemic lupus erythematosus genetic susceptibility.

CONCLUSIONS: TLR3 is overexpressed in SLE skin lesions and amplifies apoptotic and inflammatory responses to UV-irradiation in antigen-presenting cells in vitro. However, TLR3 SNPs do not impact susceptibility to the development of the disease.
PMID: 31969218 [PubMed - as supplied by publisher]

Source: Clinical and Experimental Rheumatology - January 25, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research