Toll-like receptor 3 increases antigen-presenting cell responses to a pro-apoptotic stimulus, yet does not contribute to systemic lupus erythematosus genetic susceptibility.

CONCLUSIONS: TLR3 is overexpressed in SLE skin lesions and amplifies apoptotic and inflammatory responses to UV-irradiation in antigen-presenting cells in vitro. However, TLR3 SNPs do not impact susceptibility to the development of the disease. PMID: 31969218 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

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Abstract New and Established Therapeutic Options for the Treatment of Systemic Lupus Erythematosus Abstract. Systemic lupus erythematosus is a multisystem autoimmune disease. The mainstay of therapy are antimalarials, mostly hydroxychloroquine, which should be given whenever possible. Belimumab is in the meantime a well-established add-on treatment. In the first place, joint manifestations as well as skin and fatigue improve. It was also shown to reduce severe flares and steroid use. Another therapeutic option in the future might be the interferon anifrolumab due to positive results in new studies. In case of rena...
Source: Praxis - Category: General Medicine Authors: Tags: Praxis (Bern 1994) Source Type: research
AbstractPurpose of ReviewThe review provides an update on the diagnosis, pathogenesis, and treatment of cutaneous lupus erythematosus (CLE).Recent FindingsDiagnostic challenges exist in better defining CLE as an independent disease distinct from systemic lupus erythematosus with cutaneous features and further classifying CLE based on clinical, histological, and laboratory features. Recent mechanistic studies revealed more genetic variations, environmental triggers, and immunologic dysfunctions that are associated with CLE. Drug induction specifically has emerged as one of the most important triggers for CLE. Treatment opti...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
DISCUSSION: Our case highlights how DIL should be on the differential when seemingly disparate symptoms develop in a patient receiving DIL-associated medications. Lupus is one of the "great imitators," in which symptoms can be ascribed to many different underlying causes. Although this patient's presentation may have been confounded by concomitant histoplasmosis, his improvement with cessation of hydralazine treatment argues in favor of DIL. His continued atypical serologic test results could be residual from his DIL and should normalize with time. However, it raises the question whether this bout of DIL has unma...
Source: The Permanente journal - Category: General Medicine Tags: Perm J Source Type: research
Conditions:   Chronic Inflammatory Disease;   Angioedema;   Severe Asthma;   Lupus;   Atopic Dermatitis;   Psoriatic Arthritis;   Multiple Sclerosis;   Systemic Sclerosis Interventions:   Genetic: Biobanking with genetic analysis;   Other: SF-12 questionnaire Sponsors:   University Hospital, Lille;   FHU IMMINeNT Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Authors: Wang S, Shang J, Xiao J, Zhao Z Abstract Aims: The aim was to determine whether anti-neutrophil cytoplasmic antibody (ANCA)-positive serology in patients with lupus nephritis (LN) is associated with different clinicopathologic features and outcomes.Methods: In our retrospective analysis, 283 patients were enrolled between 2013 and 2018. Thirty-six patients were ANCA-positive, and this group was compared with the remaining 247 patients who were confirmed as ANCA-negative at the time of biopsy.Results: ANCA-positive LN patients exhibited higher anti-dsDNA antibody titers and serum creatinine levels and lower...
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Medical Imagery Source Type: research
Non-coding RNAs (ncRNAs) are indispensable for CD4+ T cell differentiation and functions. By directly or indirectly regulating immune gene expression, ncRNAs give flexible instructions to guide the biological processes of CD4+ T cells and play a vital role in maintaining immune homeostasis. However, the dysfunction of ncRNAs alters the gene expression profiles, disturbs the normal biological processes of CD4+ T cells, and leads to the functional changes of CD4+ T cells, which is an underlying cause of systemic lupus erythematosus (SLE). In this review, we focus on the recent advances in the roles of ncRNAs in CD4+ T cell f...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Authors: Little AJ, Vesely MD Abstract Cutaneous lupus erythematosus (CLE) is an autoimmune disease of the skin with significant morbidity. Current treatments are often inadequate to control disease and there are no Food and Drug Administration (FDA)-approved therapies for this potentially debilitating disease, underscoring an unmet medical need. Recent insights into disease pathogenesis have implicated innate and adaptive immune components, including type I and type III interferons in the development of CLE. Promising clinical trials based on these insights are now underway. However, the full spectrum of immune ce...
Source: The Yale Journal of Biology and Medicine - Category: Universities & Medical Training Tags: Yale J Biol Med Source Type: research
Authors: Sharma M, Vignesh P, Tiewsoh K, Rawat A Abstract Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple organ systems, characterized by the production of autoantibodies. Numerous mechanisms contribute to the pathogenesis and development of autoantibodies and autoimmunity in SLE. One of the most important mechanisms is the defective function of the early complement components that are involved in clearing the immune-complexes and apoptotic debris. Major evidence supporting this hypothesis is the development of severe forms of lupus in individuals with monogenic defects ...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
Immunotherapy, Ahead of Print.
Source: Immunotherapy - Category: Allergy & Immunology Authors: Source Type: research
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