6 novel brd4 inhibitors block the pathological activation of brd4-nf κb signaling and suppress colonic inflammation in ibd mouse models

Ulcerative Colitis (UC) and Crohn ’s Disease (CD) are two major types of inflammatory bowel disease (IBD), with recurrent symptoms and significant morbidity. Long-term persistence of chronic inflammation in IBD is among the major factors contributing to neoplastic transformation and development of colitis-associated colorectal can cer. There is a lack of efficient medications for IBD, due to either limited efficacy or side effects. Antibodies against TNFα are effective therapies; however, they are expensive, and up to 40% of patients are non-responders.

Source: Gastroenterology - January 25, 2020 Category: Gastroenterology Authors: Zhiqing Liu, Gabriela Uribe, Yi Li, Wang Pingyuan, Haiying Chen, Allan Brasier, Irina Pinchuk, Jia Zhou, Bing Tian Tags: Animal Models: Pre-Clinical Treatment of Intestinal Inflammation Source Type: research