Rheologic Assessments of Sickle Cell Patients Post Allogeneic Hematopoietic Cell Transplant

Red blood cell (RBC) rheology is markedly abnormal in sickle cell disease (SCD) and is associated with clinical complications. Even fully oxygenated, sickle RBC are less deformable than those of HbAA or HbAS individuals; upon deoxygenation, deformability further declines. The goal of any cell-based therapy of curative intent should be to normalize SCD RBC rheology. We propose to functionally assess a series of post-allogeneic hematopoietic cell transplant (alloHCT) patients (pts) with SCD using rheological biomarker measurements of deformability and sickling to determine if the rheology has been normalized.

Source: Biology of Blood and Marrow Transplantation - January 24, 2020 Category: Hematology Authors: Tami John, Madeleine Lu, Celeste Kanne, Minke A.E. Rab, Richard van Wijk, Sergey Shevkoplyas, Vivien Sheehan Tags: 310 Source Type: research