Clarifying the Relationship Between Benzodiazepines and Dementia

Dementia is a global health problem, with the World Health Organization estimates placing the number of afflicted persons at around 50 million worldwide.1 Without a treatment or cure, projections are that numbers will increase dramatically around the world by 2050.2 The prevalent intervention strategy has been pursuit of a drug to cure this illness or to modify the illness course. Available medications, mainly approved for use in Alzheimer's-type dementia (AD) but extended empirically to other forms, are mainly palliative with only modest benefits in a subset of patients.
Source: Journal of the American Medical Directors Association - Category: Health Management Authors: Tags: Editorial Source Type: research

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CONCLUSION: Specialised home palliative care services may be suboptimal, and primary care services may serve as a key access point in providing baseline palliative care to people with conditions needing palliative care. Therefore, primary care services should aim to enhance their palliative care workforce. PMID: 31971075 [PubMed - as supplied by publisher]
Source: Palliative Medicine - Category: Palliative Care Authors: Tags: Palliat Med Source Type: research
The objective of this study was to identify and analyze the different scales used for pain assessment in elderly persons diagnosed with dementia, in the literature available at the Latin American level. METHOD: A systematic review was performed on the existing scales for pain assessment in elderly people diagnosed with Alzheimer's disease, vascular dementia, and dementia with Lewy bodies. RESULTS: 226 articles were retrieved from the PUBMED, BIREME, and Scielo databases, of which a total of 10 articles entered the systematic review. The instruments identified in these publications were PAINAD, Abbey, McGill, and ...
Source: Palliative and Supportive Care - Category: Palliative Care Authors: Tags: Palliat Support Care Source Type: research
In this study, by adenovirus-mediated delivery and inducible transgenic mouse models, we demonstrate the proliferation of both HCs and SCs by combined Notch1 and Myc activation in in vitro and in vivo inner ear adult mouse models. These proliferating mature SCs and HCs maintain their respective identities. Moreover, when presented with HC induction signals, reprogrammed adult SCs transdifferentiate into HC-like cells both in vitro and in vivo. Finally, our data suggest that regenerated HC-like cells likely possess functional transduction channels and are able to form connections with adult auditory neurons. Epige...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abstract While end-of-life (EOL) care has been a relatively common option for patients with terminal cancer, the utilization of EOL care in Alzheimer disease and other dementias has become available more recently. By the time end-stage dementia is present, the clinicians and caregivers become faced with multiple clinical issues-their inability to provide subjective complaints of pain and discomfort, behavioral symptoms, delirium, food refusal, and so on. In addition to providing quality EOL care to the patients, clinicians need to work with their families in an open and empathic manner, assuring that their loved o...
Source: The American Journal of Hospice and Palliative Care - Category: Palliative Care Authors: Tags: Am J Hosp Palliat Care Source Type: research
This report presents the rationale and methodology of TRAIN-AD (Trial to reduce antimicrobial use in nursing home residents with Alzheimer ’s disease and other dementias), a parallel group, cluster RCT evaluating a multicomponent intervention to improve infection management for suspected urinary tract infections (UTIs) and lower respiratory tract infections (LRIs) among NH residents with advanced dementia. TRAIN-AD is being conducted in 28 facilities in the Boston, USA, area randomized in waves using minimization to achieve a balance on key characteristics (N = 14 facilities/arm). The involvement of the...
Source: Trials - Category: Research Source Type: clinical trials
Purpose of review To identify recent advances in the field of dementia care in high-income countries. Recent findings New national and international initiatives identified support the notion of an increased commitment to face the challenge of dementia care. Recent research has documented barriers and facilitators to provide good care, and provided data on the specific needs of caregivers; the needs for better training of general practitioners; the negative influence of behavioural and psychological symptoms of dementia (BPSD); the palliative care needs; and the increased risk of dementia associated with anxiety (the p...
Source: Current Opinion in Psychiatry - Category: Psychiatry Tags: GERIATRIC PSYCHIATRY: Edited by Orestes Forlenza and Claudia Cooper Source Type: research
Over the past five years, a number of family members have shared first person accounts of their loved one's death through voluntarily stopping eating and drinking (VSED). The latest one is The Last Ten Days - Academia, Dementia, and the Choice to Die. The following is from the publisher. The Last Ten Days: Academia, Dementia, and the Choice to Die is a heartrending memoir of love, scholarship, dignity, courage, and the choices one is forced to make when given the devastating diagnosis of a terminal illness.  Spanning sixty years, this extraordinary book recounts the love story of Martha Risberg Brosio and her hus...
Source: blog.bioethics.net - Category: Medical Ethics Authors: Tags: Health Care syndicated Source Type: blogs
The number of people living with Alzheimer disease and other dementias continues to grow because of the aging of the US population. Increasingly, the issue of patient- and/or surrogate-directed withholding of oral, hand-fed food and fluids in cases of late-stage dementia is confronting caregivers. Major media outlets have covered several cases wherein patients with explicit directives or clear surrogate decision making were not allowed to face the end of their lives according to their wishes. Ethical and legal scholars, as well as many end-of-life advocacy groups, are working to develop a framework and provide guidance in ...
Source: Journal of Hospice and Palliative Nursing - Category: Nursing Tags: Ethics Series Source Type: research
Conclusion: We present a new statistical model with which EEG reactivity to external stimuli during routine presurgical evaluation can be seen as a promising avenue for the identification of patients with favorable VNS outcome. This novel method for the prediction of VNS efficacy might represent a breakthrough in the management of drug-resistant epilepsy, with wide-reaching medical and economic implications. Introduction Resective surgery is currently the best therapeutic option for treatment of patients with drug-resistant epilepsy, but a substantial number of intractable patients remains who are ineligible for such...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusions: This study found relatively shorter survival after the diagnosis of dementia when compared to other populations. CVD still appeared as a major cause of that in this particular disease. Most debilitating type of dementia was DLB/PDD.
Source: Indian Journal of Palliative Care - Category: Palliative Care Authors: Source Type: research
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