Early stage blockade of the alarmin HMGB1 reduces cartilage destruction in experimental OA

The alarmin HMGB1 is an endogenous molecule that is released into the extracellular space upon trauma or cell activation. Extracellular HMGB1 initiates innate immune responses and besides mediating inflammation, has osteoclast-activating features and mediates pain, all important features in OA. The aim of this study was to examine the involvement of HMGB1 in experimental OA and to explore the effect of local anti-HMGB1-therapy on disease progression.
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Source Type: research