Quantitative Thermal Imaging Biomarkers to Detect Acute Skin Toxicity from Breast Radiotherapy Using Supervised Machine Learning
Radiation-induced dermatitis is a common side effect of breast radiotherapy (RT). Current methods to evaluate breast skin toxicity include clinical examination, visual inspection, and patient-reported symptoms. Physiological changes associated with radiation-induced dermatitis, such as inflammation, may also increase body-surface temperature which can be detected by thermal imaging. Quantitative thermal imaging markers were identified using supervised machine-learning to develop a predictive model for radiation dermatitis.
The D.C. biotech ’s phase 3 clinical trial of a drug candidate failed to reduce symptoms among adult patients with an itchy skin condition called atopic dermatitis.
Conclusion: Skin and soft tissue lesions are relatively common in our environment with majority being benign neoplastic lesion. PMID: 32089672 [PubMed]
“What diagnosis do you want to use for those ear drops you sent on Mr. Johnson,” Jenn texted me. “ICD-L21.8 for seborrheic dermatitis?” Sigh. Welcome to prior-authorization hell. These are generic ear drops I ordered for presumed fungal infection of the external ear. The cash price for the d rops is $15 for a 10-milliliter bottle […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more.
This phase 2b, placebo-controlled, randomized clinical trial evaluates the efficacy and safety of lebrikizumab, a novel, high-affinity, monoclonal antibody targeting interleukin (IL) –13 that selectively prevents formation of the IL-13Rα1/IL-4Rα heterodimer receptor signaling complex, in adults with moderate to severe atopic dermatitis.
Toys are a reflection of the compounds used frequently in manufacturing. Allergic contact dermatitis to potties, metal toys and children's jewelry is well known, however, there is a broad range of skin risks in toys. With the objective to identify and publ...
It is well-established that asthma is common in patients with atopic dermatitis (AD).
Condition: Atopic Dermatitis Interventions: Biological: Fecal Microbial Transplantation; Biological: placebo fecal transplantation Sponsors: Tel-Aviv Sourasky Medical Center; Weizmann Institute of Science Not yet recruiting
Omalizumab, an anti-IgE medication approved to treat asthma and hives, significantly reduced children ’s atopic dermatitis severity and improved their quality of life, according to a trial in JAMA Pediatrics.
AbstractPatients with moderate-to-severe atopic dermatitis may have partial or non-durable responses to subcutaneous dupilumab, the first targeted systemic agent approved for this indication. Subsequent management approaches in such patients include optimising topical therapy, considering alternative diagnoses, adjusting the dosage of dupilumab dosage and/or using dupilumab in combination with traditional systemic immunosuppressive agents.
Abstract The stilbene tapinarof is a drug used to treat psoriasis and atopic dermatitis. Efficacy is thought to arise from its regulation of the aryl hydrocarbon receptor and nuclear factor erythroid 2-related factor 2 signaling pathways, which have also been linked to the severity of inflammatory bowel diseases. Tapinarof is produced by the gammaproteobacterial Photorhabdus genus, which infects insects and humans. Consequently, Photorhabdus represents a model to probe tapinarof structural and functional transformations. Here, we demonstrate that Photorhabdus transforms tapinarof into novel drug metabolism product...