Effect of transcatheter arterial embolisation in normal canine liver using trisacryl gelatine microspheres (Embosphere)

Publication date: Available online 23 January 2020Source: Research in Veterinary ScienceAuthor(s): Ko Nakasumi, Hiroshi Sunahara, Kazuaki Igari, Harumichi Itoh, Kazuhito Itamoto, Naoki Yamamoto, Tsuyoshi Ishikawa, Taro Takami, Isao Sakaida, Yasuho Taura, Kenji TaniAbstractThe effect of selective transcatheter arterial embolisation (TAE) using trisacryl gelatine microspheres (TGMs) in the normal canine liver was investigated. Selective embolisation was achieved by injecting TGMs into the left hepatic artery through a microcatheter in four healthy dogs. After embolisation, computed tomography (CT), biochemical analysis and histological examination were performed during a 12-week observation period. Embolisation was successful in all four dogs. Postoperative CT revealed consistent embolisation of the artery within the experimental period in three dogs. Hepatic enzyme levels slightly increased after embolisation but tapered to normal ranges. Histological examinations revealed no abnormal changes. Thus, selective TAE with TGMs was well tolerated in normal dogs and may be applicable to canine hepatocellular carcinoma.
Source: Research in Veterinary Science - Category: Veterinary Research Source Type: research

Related Links:

Publication date: 1 June 2020Source: Chemical Engineering Journal, Volume 389Author(s): Xiangjun Chen, Lixue Song, Xiliang Li, Lingyu Zhang, Lu Li, Xiuping Zhang, Chungang WangAbstractCo-delivery of hydrophilic/hydrophobic drugs in separate rooms and bimodal triggered drugs release from independent channels without mutual effect, coupled with multi-mode imaging are vitally significative for overcoming drug resistance and enhancing the therapeutic effects. Herein, we report the polydopamine@upconversion nanoparticle@mesoporous silica yolk-shell nanoparticles (PDA@UCNP@mSiO2 NPs) to simultaneously load the hydrophilic doxoru...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Authors: Navarro JG, Yang SJ, Kang I, Choi GH, Han DH, Kim KS, Choi JS Abstract Purpose: The risk of posthepatectomy liver failure (PHLF) after right hepatectomy remains substantial. Additional parameters such as computed tomography volumetry, liver stiffness measurement by FibroScan, indocyanine green retention rate at 15 minutes, and platelet count used to properly assess future liver remnant volume quality and quantity are of the utmost importance. Thus, we compared the usefulness of these modalities for predicting PHLF among patients with hepatocellular carcinoma after right hepatectomy. Methods: We retrosp...
Source: Annals of Surgical Treatment and Research - Category: Surgery Tags: Ann Surg Treat Res Source Type: research
Publication date: Available online 13 February 2020Source: European Journal of RadiologyAuthor(s): Gesa H. Poehler, Babak Alikhani, Filip Klimes, Erik F. Hauck, Kristina I. Ringe, Lena Sonnow, Frank Wacker, Hans-Jürgen RaatschenAbstractPurposeTo determine the clinical impact of CT dose management team on radiation exposure and image quality.Methods2026 clinical routine CT examinations of 1315 patients were evaluated retrospectively. A CT dose management team was established as an integral part of the radiological department. It identified 5 CT protocols (A-E), where national reference values were exceeded the most. Th...
Source: European Journal of Radiology - Category: Radiology Source Type: research
"Logic-Based Medicine" Is More Feasible than "Evidence-Based Medicine" in the Local Treatment for Hepatocellular Carcinoma. Oncology. 2020 Feb 11;:1-8 Authors: Sakon M, Kobayashi S, Wada H, Eguchi H, Marubashi S, Takahashi H, Akita H, Gotoh K, Yamada D, Asukai K, Hasegawa S, Ohue M, Yano M, Nagano H Abstract The optimal type of surgery (e.g., anatomic or non-anatomic resection) or radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) is still under debate despite numerous comparative studies based on overall survival. This debate continues not only because these endpoint...
Source: Oncology - Category: Cancer & Oncology Authors: Tags: Oncology Source Type: research
We report one such case of a 60-year-old woman, a known case of RCC of the left kidney who underwent nephrectomy, and on follow-up, PET/CT scan revealed diffuse thick nodular hypermetabolic left pleural thickening, which was later biopsied and turned out to be pleural metastases from RCC. No other site of metastases was found.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
AbstractDuring routine ultrasound examination, a hyperechoic mass was detected in the anterior segment of the liver in an 80-year-old woman with hepatitis C virus-related cirrhosis. Computed tomography and magnetic resonance imaging findings suggested a malignant tumor with abundant fibrous stroma, similar to cholangiolocellular carcinoma. However, subsequent partial hepatectomy revealed a mass characterized by abundant fibrosis without tumor cells, dilated blood vessels, and marginal ductular reaction. Accordingly, focal confluent fibrosis was diagnosed. Generally, the diagnosis of focal confluent fibrosis is straightforw...
Source: Abdominal Imaging - Category: Radiology Source Type: research
ldo J. Montano-Loza Hepatocellular carcinoma (HCC) constitutes the fourth leading cause of cancer-related mortality. Various factors, such as tumor size, tumor multiplicity, and liver function, have been linked to the prognosis of HCC. The aim of this study was to explore the prognostic significance of muscle, subcutaneous and visceral adipose tissue (VAT) mass, and radiodensity, in a cohort of 101 HCC patients treated with selective internal radiation therapy (SIRT). Muscle and adipose tissue cross sectional area (cm2/m2) and radiodensity, reported as the Hounsfield Unit (HU), were determined using pre-SIRT computed t...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
ConclusionThe use of CD-CTHA in90Y SIRT of HCC was associated with a low rate of prophylactic embolization of extrahepatic vessels while maintaining a high technical success rate of treatment and low rate of complications.Level of EvidenceLevel 4, case series.
Source: CardioVascular and Interventional Radiology - Category: Radiology Source Type: research
ConclusionsA single CT-image can be used to differentiate five contrast-enhancement phases for radiomics-based precision medicine in the most common liver neoplasms occurring in patients with or without liver cirrhosis.Graphical abstract
Source: European Journal of Radiology - Category: Radiology Source Type: research
Authors: Galastri FL, Nasser F, Affonso BB, Valle LGM, Odísio BC, Motta-Leal Filho JM, Salvalaggio PR, Garcia RG, de Almeida MD, Baroni RH, Wolosker N Abstract BACKGROUND: Drug-eluting bead transarterial chemoembolization (DEB-TACE) is an endovascular treatment to release chemotherapeutic agents within a target lesion, minimizing systemic exposure and adverse effects to chemotherapeutics. Therefore, identifying which patient characteristics may predict imaging response to DEB-TACE can improve treatment results while selecting the best candidates. Predictors of the response after DEB-TACE still have not been ...
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
More News: Cancer & Oncology | Carcinoma | CT Scan | Hepatocellular Carcinoma | Liver | Liver Cancer | Science | Urology & Nephrology | Veterinary Research