microRNA-137 downregulates MCL1 in ovarian cancer cells and mediates cisplatin-induced apoptosis

Pharmacogenomics,Volume 21, Issue 3, Page 195-207, February 2020.
Source: Future Medicine: Pharmacogenomics - Category: Genetics & Stem Cells Authors: Source Type: research

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Contributors : Radoslaw Januchowski ; Dominika Kazmierczak ; Marcin RucinskiSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiens ; synthetic constructAlthough many genes associated with the development of resistance to chemotherapy are known, the mechanisms of their regulation are still poorly understood. One of the ways to regulate gene expression is regulation at mRNA level by small noncoding RNA particles – designated as a micro RNA (miRNA). Changes in miRNA expression were also observed in cell line studyes. Downregulation of miR-31 expression correlated with taxane resistance in ovarian cancer ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens synthetic construct Source Type: research
Bulk whole genome sequencing (WGS) enables the analysis of tumor evolution but, because of depth limitations, can only identify old mutational events. The discovery of current mutational processes for predicting the tumor's evolutionary trajectory requires dense sequencing of individual clones or single cells. Such studies, however, are inherently problematic because of the discovery of excessive false positive mutations when sequencing picogram quantities of DNA. Data pooling to increase the confidence in the discovered mutations, moves the discovery back in the past to a common ancestor. Here we report a robust whole gen...
Source: eLife - Category: Biomedical Science Tags: Cancer Biology Genetics and Genomics Source Type: research
Conclusions: Given that estrogen-alone therapy has been shown to be associated with increased risk of ovarian cancer, these findings are consistent with the hypothesis that adding a progestin each day ameliorates the carcinogenic effects of estrogen on the cells of origin for all histotypes of ovarian cancer.
Source: Epidemiology - Category: Epidemiology Tags: Women’s Health Source Type: research
Conclusion: Ascertaining prostate cancer progression through self-report provides an efficient and valid approach to enhancing existing cancer cohorts with updated data on progression status. See video abstract at, http://links.lww.com/EDE/B658.
Source: Epidemiology - Category: Epidemiology Tags: Cancer Source Type: research
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsSerum HE4 levels can potentially be used as a marker to differentiate between benign and malignant ovarian disease with elevated serum CA125 levels. The high specificity of HE4 was superior in identifying benign ovarian disease. We recommend increasing the cutoff values of HE4 in premenopausal patients and decreasing the cutoff values in postmenopausal patients for increased accuracy in the differential diagnosis of patients with elevated CA125 levels.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
ConclusionOn the basis of these findings, OT is a promising agent for ameliorating harmful effects of MTX on rat ovaries in an experimental model.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
To meet clinical needs, fluorescence-guided surgery has emerged as a new technique that guides surgeons in the resection of cancerous tissue by highlighting tumour lesions during surgery. We aimed to evaluate ...
Source: World Journal of Surgical Oncology - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
British Journal of Cancer, Published online: 06 April 2020; doi:10.1038/s41416-020-0822-xCombining measures of immune infiltration shows additive effect on survival prediction in high-grade serous ovarian carcinoma
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
by Sarmi Nath, Ganesh Nagaraju FANCJ helicase mutations are known to cause hereditary breast and ovarian cancers as well as bone marrow failure syndrome Fanconi anemia. FANCJ plays an important role in the repair of DNA inter-strand crosslinks and DNA double-strand breaks (DSBs) by homologous recombination (HR). Nonetheless, th e molecular mechanism by which FANCJ controls HR mediated DSB repair is obscure. Here, we show that FANCJ promotes DNA end resection by recruiting CtIP to the sites of DSBs. This recruitment of CtIP is dependent on FANCJ K1249 acetylation. Notably, FANCJ acetylation is dependent on FANCJ S990 phosp...
Source: PLoS Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
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