Association between rs4149056 variant in SLCO1B1 and early discontinuation of statin after acute myocardial infarction

Pharmacogenomics,Volume 21, Issue 3, Page 163-172, February 2020.
Source: Future Medicine: Pharmacogenomics - Category: Genetics & Stem Cells Authors: Source Type: research

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This study aimed to explore the cardiologist adherence with ACC/AHA guidelines on discharge medications for patients admitted with acute coronary syndrome (ACS), assess the predictors of cardiologist non-adherence and measure the impact of pharmacist intervention on improving guideline adherence.MethodsThe study included two consecutive phases: observation and intervention. It was carried out at Al-Najaf Center for Cardiac Surgery and Catheterization, Iraq, from August through December 2018. In the observation phase, medical records were reviewed retrospectively in order to assess the adherence to guideline. The interventi...
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
The 2016 review for the US Preventive Services Task Force on statins for prevention of cardiovascular disease in adults had errors in the analysis of statins vs placebo and cardiovascular mortality. For the JUPITER trial, we interpreted “MI, stroke or cardiovascular death” as reported in the main trial publication as “myocardial death, stroke death, or cardiovascular death,” when it meant “nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death.” Therefore, the analysis erroneously included nonfatal myo cardial infarction and stroke events (83/8901 vs 157/8901 in the ros...
Source: JAMA - Category: General Medicine Source Type: research
Authors: Alwi I Abstract Over more than two decades, the concept of atherosclerosis has developed and lead to inflammatory hypothesis. Inflammation plays an important role on pathogenesis of atherothrombosis and coronary heart disease (CHD), including acute coronary syndrome (ACS). Although the management of ACS has been demonstrated to be beneficial for secondary prevention of coronary heart disease (such as using statin and aspirin) and also seemed to have positive effect on inflammation, the identification of effective management, specifically targeting inflammation, has been not been comprehensively understood....
Source: Acta medica Indonesiana - Category: Internal Medicine Tags: Acta Med Indones Source Type: research
If you have a CT heart scan score (also called coronary calcium score), what effect do statin cholesterol drugs have on stopping or slowing the increase in score? (Increasing scores pose increasing risk for heart attack and other cardiac events.) NONE. If you do nothing at all, the score increases by 25% per year, on average. If you take a statin drug, aspirin, and follow a low-fat diet, what my colleagues call “optimal medical therapy,” the score increases . . . 25% per year—no difference. Yet this is the “solution” that conventional doctors push on their patients, a “treatment” t...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Open cholesterol coronary calcium ct scan do statin drugs reduce heart scan scores reduce coronary calcium reverse coronary calcium reverse heart disease undoctored wheat belly Source Type: blogs
CONCLUSIONS: Non-fasting TG could be considered as a substitute for fasting TG as a risk stratification for future CV events among Japanese diabetic patients. PMID: 32023582 [PubMed - as supplied by publisher]
Source: Circulation Journal - Category: Cardiology Authors: Tags: Circ J Source Type: research
A study of 40,000 people in Finland suggests unhealthy habits could render the drugs - which are supposed to prevent life-threatening events such as heart attack and stroke - pointless.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
ConclusionPrevious and continuous enrollment in the DMP CAD for patients after AMI is a promising strategy as it enhances guideline-recommended medication, reduces health care expenditures and the risk of death.
Source: The European Journal of Health Economics - Category: Health Management Source Type: research
ConclusionThis prospective study suggests that RAAS inhibitor therapy provides mid-term beneficial effects on outcomes in MINOCA patients; in contrast, dual antiplatelet, β-blocker and statin therapy had no effects on mortality and MACE. These results should be considered preliminary and warrant confirmation from larger studies.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
(Natural News) We’ve all had it drilled into our heads that high cholesterol is bad and bringing it down with statins can prevent a heart attack. However, that doesn’t explain why many people who take statins still end up developing cardiovascular disease. A recent study shows that there’s far more to the cardiovascular disease equation...
Source: - Category: Consumer Health News Source Type: news
This study aimed to investigate the severity of coronary artery disease (CAD) in patients with ATX. METHODS: A total of 394 patients with CAD undergoing percutaneous coronary intervention (PCI) at Chiba University Hospital between June 2016 and February 2018 were enrolled. Soft X-ray radiography of Achilles tendon was performed, and a maximum thickness of 9 mm or more was regarded as ATX. Heterozygous FH was diagnosed according to the diagnostic criteria proposed by the Japan Atherosclerosis Society in 2017. CAD severity was assessed by SYNTAX score before the first PCI during the study period. RESULTS: There wer...
Source: Journal of Cardiology - Category: Cardiology Authors: Tags: J Cardiol Source Type: research
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