nodal relapse 9y after RP and PORT for prostatic carcinoma

75 years old patient, with controlled diabetes and hypertension, very fit. he underwent in 2009, a radical prostatectomy followed 30 fractions of adjuvant 3D conformal radiation therapy to the prostatic bed only. in 2018: PSA rise to 2.16 2019: PSA 2.16 Pet PSMA showed a 7 mm LN at the level of L4-5 secondary lesion, with no recurrence in the tumor bed, neither in bone or other LNs. He was put on decapeptyl + casodex. please vote the poll
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Radiation Oncology Source Type: forums

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Objectives Hepatocellular carcinoma can develop after hepatitis C virus eradication. We developed a new hepatocellular carcinoma risk score (HCC-SVR score) based on independent predictors for chronic hepatitis C after sustained virological response. Methods Between 2003 and 2016, a total of 1193 patients with chronic hepatitis C who achieved sustained virological response through antiviral therapy were included (669 for training cohort and 524 for validation cohort). The HCC-SVR score was developed using multivariate Cox proportional hazards regression modelling. Results Hepatocellular carcinoma (n = 19) occurred m...
Source: European Journal of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research
RARITAN, N.J., February 3, 2020 – The Janssen Pharmaceutical Companies of Johnson &Johnson announced today multiple data presentations from a robust solid tumor portfolio that will be featured at the American Society of Clinical Oncology Genitourinary (ASCO GU) Cancers Symposium, taking place February 13-15 in San Francisco. Company-sponsored data presentations will include clinical results for ERLEADA® (apalutamide) and niraparib in prostate cancer; and BALVERSA™ (erdafitinib) in bladder cancer. “We are committed to improving outcomes in patients with prostate and bladder cancer where high unmet ...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
Abstract Hepatocellular carcinoma (HCC) accounts for about 80-90% of all liver cancers and is found to be the third most common cause of cancer mortality in the Asia-Pacific region. Risk factors include hepatitis B and C virus, cirrhosis, aflatoxin-contaminated food, alcohol, and diabetes. Surgically removing the tumor tissue seems effective but a high chance of recurrence has led to an urgent need to develop novel molecules for the treatment of HCC. Clinical management with sorafenib is found to be effective but it is only able to prolong survival for a few months. Various side effects like gastrointestinal and a...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
Authors: Kumar R, Goh BG, Kam JW, Chang PE, Tan CK Abstract Background and Aim: Non-alcoholic liver disease and alcoholic liver disease begin as simple steatosis that may progress to steatohepatitis and ensuing liver-related complications such as cirrhosis and hepatocellular carcinoma (HCC). We explored differences in characteristics between non-alcoholic steatohepatitis (NASH) and alcoholic steatohepatitis-related (ASH) HCC. Methods: NASH and ASH patients were identified from our department's prospective HCC database. A total of 54 and 45 patients met predefined inclusion and exclusion criteria for the NASH-HC...
Source: Clinical and molecular hepatology - Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research
This report provides additional evidence in support of N. meningitidis as a cause of cellulitis. PMID: 31901921 [PubMed - in process]
Source: Malaysian Journal of Pathology - Category: Pathology Tags: Malays J Pathol Source Type: research
CONCLUSION: NAFLD-related HCC was found in non-cirrhotic patients in 42% of cases, alpha-fetoprotein level was normal in 63% and "steatohepatitic HCC" was the predominant histological type. Immunoexpression of K19 and/or Ki-67 occurred in 32% of the nodules and were associated with intratumoral inflammation and ballooning, suggesting that HCC in MtS may be preferentially "an inflammatory, non-proliferative subtype of HCC". PMID: 31858523 [PubMed - as supplied by publisher]
Source: Histology and Histopathology - Category: Cytology Tags: Histol Histopathol Source Type: research
A 63-year-old white male presented with maxillary gingival swelling for a 6-month duration. Medical history revealed diabetes and hypertension. Extraoral examination was noncontributory. Intraoral exam showed a red bleeding lobulated nodule measuring 5.0  × 3.0 cm in the left maxillary gingiva. The presumptive diagnosis was nonneoplastic reactive lesion. An incisional biopsy was performed and histopathologic diagnosis was unspecific malignant neoplasm. The initial immunohistochemical panel was inconclusive.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
This study aims to report a case of lichenoid mucositis and to carry out a literature review highlighting the relevant issues for differential diagnosis. A 69-year-old man, a chronic smoker, reported complaints of “alteration in his cheek.” During anamnesis, chronic obstructive pulmonary disease, diabetes, and hypertension were reported, with medication use of antiulcer drugs, antihypertensive drugs, and oral hypoglycemic agents. In addition, there was a family history of squamous cell carcinoma in the to ngue.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
M.S.S. is a 54-year-old white female patient with main complaint: "For more than 2 years appeared a small white spot on the tongue that had been increased." The anamnesis revealed no history of alcohol and tobacco consumption and diabetes and hypertension controlled with medication and diet. The patient reported previous biopsy 2 months ago, whose histopathologic diagnosis was leukoplakia with mild epithelial dysplasia. Intraoral clinical examination detected a leukoplastic lesion with a granular surface located on the right border of the tongue.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
This study aimed to evaluate the utility of the AACI for predicting long-term survival in patients with surgically treated non-metastatic clear cell RCC (ccRCC).MethodsData from 698 patients with non-metastatic ccRCC who underwent radical or partial nephrectomy as primary therapy from a multi-institutional Korean collaboration between 1988 and 2015 were retrospectively analyzed. Clinicopathological variables and survival outcomes of those with AACI scores  ≤ 3 (n = 324), 4–5 (n = 292), and ≥ 6 (n = 82) were compared.ResultsPatients with a hig...
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
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