Epigenetic histone modulation contributes to improvements in inflammatory bowel disease via EBI3.

In conclusion, our results reveal that under inflammatory conditions, EBI3 is upregulated by the epigenetic mechanism of histone acetylation. The in vivo data show that the deficiency of EBI3 plays a key role in colitis manifestation. Concordantly, our data suggest that conditions promoting histone acetylation, such as upon HDACi application, improve colitis by a mechanism involving the local formation of the anti-inflammatory cytokine IL-35.
PMID: 31955243 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - January 17, 2020 Category: Cytology Authors: Wetzel A, Scholtka B, Gerecke C, Kleuser B Tags: Cell Mol Life Sci Source Type: research