Primary ciliary dyskinesia patients have the same P. aeruginosa clone in sinuses and lungs

Similar to patients with cystic fibrosis (CF) and non-CF bronchiectasis, patients with primary ciliary dyskinesia (PCD) are prone to recurrent or chronic lung infections with Pseudomonas aeruginosa. Chronic P. aeruginosa lung infection has a prevalence of up to 39% in patients with PCD [1] and is associated with structural damage, affecting lung function. Treatment of P. aeruginosa infection is challenging because P. aeruginosa adapts to the host environment through genotypic/phenotypic changes, promoting a reduced immune response [2].

Source: European Respiratory Journal - January 15, 2020 Category: Respiratory Medicine Authors: Arndal, E., Johansen, H. K., Haagensen, J. A. J., Bartell, J. A., Marvig, R. L., Alanin, M., Aanaes, K., Hoiby, N., Nielsen, K. G., Backer, V., von Buchwald, C. Tags: Original Articles: Research letters Source Type: research