pBrain: A novel pipeline for Parkinson related brain structure segmentation

Publication date: Available online 15 January 2020Source: NeuroImage: ClinicalAuthor(s): José V. Manjón, Alexa Bertó, José E. Romero, Enrique Lanuza, Roberto Vivo-Hernando, Fernando Aparici-Robles, Pierrick CoupeAbstractParkinson is a very prevalent neurodegenerative disease impacting the life of millions of people worldwide. Although its cause remains unknown, its functional and structural analysis is fundamental to advance in the search of a cure or symptomatic treatment. The automatic segmentation of deep brain structures related to Parkinson`s disease could be beneficial for the follow up and treatment planning. Unfortunately, there is not broadly available segmentation software to automatically measure Parkinson related structures. In this paper, we present a novel pipeline to segment three deep brain structures related to Parkinson's disease (substantia nigra, subthalamic nucleus and red nucleus). The proposed method is based on the multi-atlas label fusion technology that works on standard and high-resolution T2-weighted images. The proposed method also includes as post-processing a new neural network-based error correction step to minimize systematic segmentation errors. The proposed method has been compared to other state-of-the-art methods showing competitive results in terms of accuracy and execution time.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research

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CONCLUSIONS: The Korean MDS-UPDRS has the same overall structure as the English MDS-UPDRS. Our translated scale can be designated as the official Korean MDS-UPDRS. PMID: 33029970 [PubMed]
Source: Journal of Clinical Neurology - Category: Neurology Tags: J Clin Neurol Source Type: research
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Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Parkinson's disease (PD) patients with freezing of gait (FOG) can suddenly lose their forward moving ability leading to unexpected falls. To overcome FOG and avoid the falls, a real-time accurate FOG detection or prediction system is desirable to trigger o...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Freezing of gait (FOG) is a sudden cessation of locomotion in advanced Parkinson's disease (PD). A FOG episode can lead to falls, decreased mobility, and decreased overall quality of life. Prediction of FOG episodes provides an opportunity for intervention...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
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Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
Parkinson ’s disease (PD) is a common neurodegenerative condition associated with a wide range of motor and non-motor symptoms. There has been increasing interest in the potential benefit of performing arts as ...
Source: BMC Neurology - Category: Neurology Authors: Tags: Research article Source Type: research
Freezing of gait (FOG) in Parkinson's disease (PD) is the main cause of falling and greatly decreases the quality of life. The causes of FOG include not only motor symptoms such as rigidity and bradykinesia, but also non-motor symptoms such as cognitive decline and anxiety.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Correspondence Source Type: research
Authors: Lu R, Xu Y, Li X, Fan Y, Zeng W, Tan Y, Ren K, Chen W, Cao X Abstract Parkinson's disease (PD) decreases the quality of life of the affected individuals. The incidence of PD is expected to increase given the growing aging population. Motor symptoms associated with PD render the patients unable to self-care and function properly. Given that several drugs have been developed to control motor symptoms, highly sensitive scales for clinical evaluation of drug efficacy are needed. Among such scales, the objective and continuous evaluation of wearable devices is increasingly utilized by clinicians and patients. S...
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
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Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
Conditions:   Parkinson Disease;   Cognition Disorder;   Motor Disorders Intervention:   Other: Cognitive training Sponsors:   Federal University of Paraíba;   Universidade Federal do Rio Grande do Norte Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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